Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06539078
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-18
Brief Title:
Skeletal Muscle Mitochondria in Ageing
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Exercise as a Countermeasure Against the Effects of Ageing on Muscle Mitochondria Diffusive Oxygen Transport and Muscle Volume
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AGAMEMNON
Brief Summary:
Healthy ageing is associated with the loss of muscle mass and physical function As a result older people are limited in their independence The aging of muscles typically begins around the age of 30 From this age onward muscle strength muscle mass and the maximum oxygen uptake of muscles decrease The reasons for this are not entirely clear but it seems to be partly related to how oxygen moves from our blood vessels to the muscles and how muscles burn energy The precise role of age and physical fitness as well as whether exercise can counteract the effects of ageing is still unknown Therefore in this study we aim to investigate the muscle function of both physically active and inactive young and middle-aged individuals We hypothesise that endurance training can mitigate some of the effects of ageing
Detailed Description:
Healthy ageing is associated with a loss of muscle mass and physical function This loss of physical function is underpinned by reductions in characteristics such as muscle strength power and maximal oxygen uptake VO2max reflecting exercise capacity However the causal contributors to these age-associated impairments and the role of exercise training status in mitigating them remain poorly defined Skeletal muscle mitochondrial function has been proposed to be a key contributor to age-associated effects on physical function however many conflicting results are present in the extant human literature Moreover diffusion of oxygen from capillaries to mitochondria is a key determinant of VO2max however whether the skeletal muscle diffusive capacity for oxygen DmO2 declines with age is unknown A new technique utilizing near-infrared spectroscopy NIRS will enable the non-invasive assessment of skeletal muscle diffusive capacity in young and elderly subjects for the first time to resolve this issue The primary aims of this study are therefore to 1 compare DmO2 derived via NIRS between young sedentary young endurance-trained older sedentary and older endurance-trained subjects 2 to compare non-invasive ie with NIRS and 31phosphorous magnetic resonance spectroscopy 31P-MRS and invasive ie measures of mitochondrial morphology and respiration obtained by skeletal muscle biopsy markers of mitochondrial function between the same groups and 3 to assess the relationships between DmO2 mitochondrial measures and assessments of capillarization with functional measurements of muscle strength power and VO2max
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None