Ignite Creation Date:
2024-10-26 @ 3:37 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06539039
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-08-01
Brief Title:
Periodontal Therapy Effect on the Ratio of TNF-α to IL-10 in Periodontis WithOut DM
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Non Surgical Periodontal Therapy on the Ratio of TNF-α to IL-10 in Periodontitis Patients With Diabetics Mellites
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontitis is a chronic inflammatory disease affecting the periodontium characterized by irreversible damage to the gingiva periodontal ligament and alveolar bone It is prevalent among adults significantly impacting oral health and quality of life This study investigates the effect of non-surgical periodontal therapy NSPT on the levels of Tumor Necrosis Factor-alpha TNF-α and Interleukin-10 IL-10 in periodontitis patients with and without diabetes mellitus type II
Detailed Description:
A single-blinded randomized clinical trial was conducted on 36 patients with generalized periodontitis recruited from Ain-Shams Universitys outpatient clinic Patients were divided into three groups poorly controlled diabetes with periodontitis HbA1c 7 controlled diabetes with periodontitis HbA1c 7 and non-diabetic periodontitis Full-mouth NSPT was performed and clinical parameters Plaque Index Bleeding Index Pocket Depth Clinical Attachment Level were assessed at baseline and eight weeks post-treatment Venous blood samples were collected to measure TNF-α and IL-10 levels using ELISA kits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None