Official Title: Adaptations in Postprandial Metabolic Flexibility Following a Three-day High-fat Diet
Status: NOT_YET_RECRUITING
Status Verified Date: 2024-08
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: No
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: MetFlexHFD
Brief Summary: The purpose of this study is to understand how the bodys response after a meal is influenced by insulin and sugar in the blood The primary question this study seeks to address is what is the effect of reduced insulin sensitivity on postprandial metabolic flexibility to an oral glucose tolerance test We will recruit 50 adults ages 20-45 50 female who are otherwise healthy no known clinical diagnosis into our non-randomized crossover trial to determine the effect of changes in insulin sensitivity on metabolic response to feeding Insulin sensitivity will be decreased using a three-day high-fat diet HFD with extra calories Whole-body metabolism will be measured during a standard 75-gram oral glucose tolerance test OGTT Metabolic response to feeding eg OGTT will be compared before and after the HFD and compared with the control diet to understand the effect of decreased insulin sensitivity on the metabolic response to feeding The role of biological sex as a moderator of the effect of increased insulin resistance on postprandial metabolic flexibility will also be investigated