Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06537141
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-12
Brief Title:
Role of Embolization of Thyroid Arteries as a Treatment for Different Thyroid Disorders
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Role of Selective Embolization of Thyroid Arteries SETA as an Adjunctive or Definitive Treatment for Different Thyroid Disorders
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the safety and efficacy of selective embolization of thyroid arteries SETA as adjunctive or definitive treatment in different thyroid disorders
Detailed Description:
In graves disease Traditional forms of treatment of the thyroid diseases pharmacotherapy radioiodine therapy and surgery can not always be applied Intolerance side effects of antithyroid drugs low iodine uptake high risk of surgery or disagreement with the proposed treatment was the reason for seeking alternative treatment methods
Also in cases of large sized thyroid nodule and retrosternal extension surgery may carries out a lot of comorbidities
With the development of interventional radiology and gained experience in the use of arterial embolization this method has become possible to use in treatment of thyroid diseases The essence of this treatment is to shut down blood flow in major arteries of the thyroid by direct injection of embolizing materials PVA into the vessels
The consequence of acute ischemia is necrosis of the glandular tissue in a field being supplied by this artery Further repair processes and fibrosis lead to a reduction of active thyroid hormone synthesis and restriction of thyroid gland Effects of embolization on angiogenesis apoptosis and autoimmune reactions contribute to compensation thyroid function and significant reduction a goiter volume in course of Graves disease Preoperative selective embolization of a huge goiter or thyroid cancer improves surgery outcomes reduces the risk of hemorrhage and damage to surrounding tissue Palliative use of embolization in advanced stages of thyroid cancer reduces symptoms and improves quality of life Little invasive nature of this procedure the lack of serious undesirable coincidence makes embolization of thyroid arteries an attractive form of a therapy which may become a therapeutic option in many difficult clinical situations and improve the clinical effectiveness of treatment of thyroid disease
Also in cases of large sized thyroid nodule and retrosternal extension surgery may carries out a lot of comorbidities
With the development of interventional radiology and gained experience in the use of arterial embolization this method has become possible to use in treatment of thyroid diseases The essence of this treatment is to shut down blood flow in major arteries of the thyroid by direct injection of embolizing materials PVA into the vessels
The consequence of acute ischemia is necrosis of the glandular tissue in a field being supplied by this artery Further repair processes and fibrosis lead to a reduction of active thyroid hormone synthesis and restriction of thyroid gland Effects of embolization on angiogenesis apoptosis and autoimmune reactions contribute to compensation thyroid function and significant reduction a goiter volume in course of Graves disease Preoperative selective embolization of a huge goiter or thyroid cancer improves surgery outcomes reduces the risk of hemorrhage and damage to surrounding tissue Palliative use of embolization in advanced stages of thyroid cancer reduces symptoms and improves quality of life Little invasive nature of this procedure the lack of serious undesirable coincidence makes embolization of thyroid arteries an attractive form of a therapy which may become a therapeutic option in many difficult clinical situations and improve the clinical effectiveness of treatment of thyroid disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None