Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06534944
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-07-30
Brief Title:
NAD Supplementation and Vascular Health in PAD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Nicotinamide Adenine Dinucleotide NAD Supplementation on Systemic Vascular Health in Peripheral Artery Disease
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation cerebrovascular hemodynamics cognitive function in older adults with peripheral artery disease
Detailed Description:
Peripheral artery disease PAD is a prevalent age-related vascular pathology and the third leading cause of cardiovascular morbidity and mortality among older adults Accumulating evidence indicates that PAD is associated with generalized endothelial dysfunction that expands from the periphery to central circulation and from macro- to microcirculation One of the mechanisms that contributes to vascular dysfunction in aging and age-related diseases is the decline in the Nicotinamide Adenine Dinucleotide NAD levels Importantly recent reports indicate that age-associated decreases in NAD are exacerbated in age-related diseases including in patients with PAD Clinical data demonstrate that NAD levels can be increased via per os supplementation with the NAD precursor nicotinamide riboside NR Although few ongoing studies provide initial evidence that NAD supplementation with NR may benefit vascular health in older adults including potential improvements in blood pressure and aortic stiffness the effects of NR supplementation on vascular health in PAD is understudied This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation cerebrovascular hemodynamics cognitive function in older adults with peripheral artery disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None