Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06528977
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-08
Brief Title:
Western Diet on Cardiometabolic and Immune Function
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effects of a 10-day Western Diet on Cardiometabolic and Immune Function in Midlife Adults
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
WD
Brief Summary:
This study will implement a Western Diet WD to understand cardiometabolic and immune function in middle-aged adults 50- 64 years old Vascular health intestinal permeability and T-cell function will be examined before during and after the WD The WD is a 10-day diet and will consist of 25 of total energy from added sugars
Detailed Description:
Aging is the primary risk factor for Alzheimers disease AD which is the most common form of dementia and among the fastest-growing causes of morbidity and mortality in the United States The risk factors for AD emerge during midlife and are similar to cardiovascular diseases one of which has particular interest is high blood pressure The impact of blood vessels and high blood pressure are made worse by poor lifestyle habits including eating a Western Diet WD that contains processed food and high amounts of added sugars eg foods containing high amounts of fructose with little to no fiber intake from fruits and vegetables Previous data indicates a 10-day WD can acutely increase triglycerides and blood pressure These cardiometabolic changes are thought to involve the immune system however it is not exactly known how a WD triggers an inflammatory response This project aims to determine the role of diet-induced changes in gut health and the function of the immune system T-cells in midlife adults It is hypothesized that eating a WD will acutely make the small intestine more permeable concurrent with activation of the immune system measured via T-cell function To test this hypothesis gut health T-cell function and blood vessel function will be measured before during and after a 10-day WD The data generated from this project will help bridge the gap in understanding the relation between diet and the immune system The results will support future grant proposals to the National Institutes of Health aimed at using dietary interventions to protect against high blood pressure and cognitive impairment in mid-life adults
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None