Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06526520
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-25
Brief Title:
Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the levels of Relaxin in different types of endometrial preparation for a frozen embryo transfer cycle Up to now it is unclear whether ovulation with a functional corpus luteum CL will be present in a natural proliferative phase NPP endometrial preparation approach
Detailed Description:
The last years have seen a distinct shift from fresh fresh ET to frozen embryo transfer FET cycles Furthermore it became obvious that the endometrial preparation approach has a significant impact on the course of the pregnancy and that a HRT endometrial preparation approach is associated with a higher risk for bleeding and miscarriages in early pregnancy and for the development of pregnancy induced hypertension and pre-eclampsia later in pregnancy
These conditions are attributed to the absence of a CL in the HRT approach Lately a new endometrial preparation approach is discussed and performed the so called natural proliferative phase protocol in which the follicle growth is monitored and when the lining is deemed to have a sufficient thickness and the triple lining pattern exogeneous progesterone is started to induce secretory transformation before spontaneous ovulation Despite some studies showing that exogeneous progesterone administration might induce ovulation it is not clear whether there will be a CL producing Relaxin in the NPP approach
These conditions are attributed to the absence of a CL in the HRT approach Lately a new endometrial preparation approach is discussed and performed the so called natural proliferative phase protocol in which the follicle growth is monitored and when the lining is deemed to have a sufficient thickness and the triple lining pattern exogeneous progesterone is started to induce secretory transformation before spontaneous ovulation Despite some studies showing that exogeneous progesterone administration might induce ovulation it is not clear whether there will be a CL producing Relaxin in the NPP approach
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None