Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06526442
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-17
Brief Title:
MRE for Diagnosis of Pancreatic Masses
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Experimental and Clinical Study of Three-dimensional Magnetic Resonance Elastography to Evaluate Pancreatic Cancer and Interstitial Fibrosis
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MREDPCM
Brief Summary:
Pancreatic ductal adenocarcinoma PDAC accounts for 85-95 of pancreatic cancer and is one of the deadliest tumors in the world with a survival rate of less than 8 and identifying key prognostic or predictive factors facilitates risk stratification and prospective assessment in clinical trials The extracellular matrix ECM surrounding PDAC often exhibits a large number of interstitial fibrosis which is closely related to the formation development and metastasis of PDAC High order three-dimensional MR elastography 3D-MRE allows non-invasive measurements of sheer stiffness in normal pancreas and pancreatic lesions However there are no reports about the application of MRE imaging biomarkers to predict the prognosis of PDAC at home and abroad
Detailed Description:
Pancreatic ductal adenocarcinoma PDAC accounts for 85-95 of pancreatic cancer and is one of the deadliest tumors in the world with a survival rate of less than 8 and identifying key prognostic or predictive factors facilitates risk stratification and prospective assessment in clinical trials
The extracellular matrix ECM surrounding PDAC often exhibits a large number of interstitial fibrosis which is closely related to the formation development and metastasis of PDAC Although interstitial composition is considered a double-edged sword influencing cancer biological progression and modification in multiple complex ways experimental studies consistently demonstrate that hardening of ECM in PDAC accelerates PDAC progression and is significantly associated with shorter survival If investigators can noninvasively detect the mechanical properties hardness of human PDAC before treatment it will be helpful to describe the biological characteristics of tumors predict the prognosis of patients and choose the right clinical treatment decision
High order three-dimensional MR elastography 3D-MRE allows non-invasive measurements of sheer stiffness in normal pancreas and pancreatic lesions However there are no reports about the application of MRE imaging biomarkers to predict the prognosis of PDAC at home and abroad
The extracellular matrix ECM surrounding PDAC often exhibits a large number of interstitial fibrosis which is closely related to the formation development and metastasis of PDAC Although interstitial composition is considered a double-edged sword influencing cancer biological progression and modification in multiple complex ways experimental studies consistently demonstrate that hardening of ECM in PDAC accelerates PDAC progression and is significantly associated with shorter survival If investigators can noninvasively detect the mechanical properties hardness of human PDAC before treatment it will be helpful to describe the biological characteristics of tumors predict the prognosis of patients and choose the right clinical treatment decision
High order three-dimensional MR elastography 3D-MRE allows non-invasive measurements of sheer stiffness in normal pancreas and pancreatic lesions However there are no reports about the application of MRE imaging biomarkers to predict the prognosis of PDAC at home and abroad
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None