Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06525844
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-24
Brief Title:
Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clinical and Radiographic Outcomes With the Use of I-PRF in Mature Permanent Teeth With Symptomatic Irreversible Pulpitis A Randomized Control Trial
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Root canal therapy RCT is a classical and effective treatment that is currently utilised in dental practice offering high success rates for pulp and periapical diseases however teeth after RCT are susceptible to altered pulp defence and sensory function even fractures as a consequence of pulp loss Furthermore several studies have highlighted that the actual failure rate of standard root canal treatments performed in general practice is significantly higher than expected Moreover these treatments are lengthy and costly and are often subject to retreatment Inherent in this procedurerct is loss of dental hard tissue and subsequent weakening of the treated toothmaking them more prone to fracture Therefore less invasive alternative strategies could be used to treat pulpitis even when irreversible
Murray et al proposed the term Regenerative endodontic treatment RET in 2007 based on a tissue engineering concept stem cells biomimetic scaffolds and bioactive growth factors The 2016 American Association of Endodontists AAE guidelines formally defined RET as a collection of biologically based procedures designed to replace damaged tooth structures including dentine and root structures as well as cells of the pulp-dentine complex
Murray et al proposed the term Regenerative endodontic treatment RET in 2007 based on a tissue engineering concept stem cells biomimetic scaffolds and bioactive growth factors The 2016 American Association of Endodontists AAE guidelines formally defined RET as a collection of biologically based procedures designed to replace damaged tooth structures including dentine and root structures as well as cells of the pulp-dentine complex
Detailed Description:
Mature permanent teeth with Irreversible Pulpitis have traditionally been managed with root canal treatment However this procedure significantly reduces the survival rate of tooth Acknowledging the inherent healing potential of an infection-free pulp attempts have been made to use pulpotomy as a treatment modality in permanent teeth with complete root development exhibiting symptoms of irreversible pulpitis where the radicular pulp is still healthy Besides the issues associated with coronal pulpotomy in permanent teeth are uncertainty on the pulpal status at the time of treatment and lack of predictability Moreover there is a dearth of information in the literature that assesses the healing potential of pulp tissue in terms of clinical and radiographic outcomes in mature teeth with irreversible pulpitisRegenerative endodontic therapy RET has attracted increasing attention with the development of tissue engineering RET applies the concept of tissue engineering to achieve revascularization innervation and restoration of odontoblastic layers Unlike root canal therapy the disinfected canals are filled with vital tissue in RET rather than biocompatible nonvital foreign materials While several studies have explored the potential of pulp regeneration for infected teeth most studies are limited to the treatment of immature necrotic teeth For mature permanent teeth the vital pulp is also of great importance in enhancing the immune system in root canals promoting dentin deposition under chronic stimuli and preventing discolouration However most of the reports of pulp regeneration in mature teeth are case reports or case series as mature teeth have fewer stemprogenitor cells have narrower apical pathways for cell migration and are more difficult to disinfect Hence it is of great urgency to develop an improved RET procedure to maximise the regeneration potential of mature teeth and extend the indications of RET
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None