Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06523335
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Improving Independent Multi-joint Arm Control After Stroke
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NICE
Brief Summary:
The purposes of this study include
1 - To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke
2 - To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke
1 - To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke
2 - To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke
Detailed Description:
Stroke is a leading cause of long-term disability in the United States Of the more than 700000 Americans who experience a stroke each year two-thirds survive 69 of patients who were admitted to a rehabilitation unit following stroke have mild to severe upper extremity dysfunction Currently there are more than seven million stroke survivors in the US many of whom have long-term motor and sensory impairments especially in the arm The objective of this study involves both scientific and clinical aspects
For the first purpose intermuscular coordination patterns emerging under isometric reaching and dynamic conditions will be identified to predict impairment of both non-motion or motion-involved task performance and severity of motor impairment after stroke This aim will enroll 15 age-matched age of 40-75 yo healthy adults and 25 adult age of 40-75 yo stroke survivors Each stroke participant will have two visit sessions while age-matched will have a single measurement session
For the second purpose in total 74 stroke survivors will perform an electromyographic signal-guided exercise through human-machine interaction to ameliorate motor impairment post-stroke by normalizing abnormal intermuscular coordination patterns in the arm after stroke and improve motor impairment also assessment of the intermuscular coordination UE Fugl-Meyer FM and Action Research Arm Test ARAT will be performed Participants will have three visits per week for six weeks for training sessions Finally to test retention of the intervention effect they will perform two assessment sessions one and three months after finishing the training
For the first purpose intermuscular coordination patterns emerging under isometric reaching and dynamic conditions will be identified to predict impairment of both non-motion or motion-involved task performance and severity of motor impairment after stroke This aim will enroll 15 age-matched age of 40-75 yo healthy adults and 25 adult age of 40-75 yo stroke survivors Each stroke participant will have two visit sessions while age-matched will have a single measurement session
For the second purpose in total 74 stroke survivors will perform an electromyographic signal-guided exercise through human-machine interaction to ameliorate motor impairment post-stroke by normalizing abnormal intermuscular coordination patterns in the arm after stroke and improve motor impairment also assessment of the intermuscular coordination UE Fugl-Meyer FM and Action Research Arm Test ARAT will be performed Participants will have three visits per week for six weeks for training sessions Finally to test retention of the intervention effect they will perform two assessment sessions one and three months after finishing the training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None