Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06522152
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation MAT at 15 Years
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation MAT at 15 Years
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MAT 15 Y
Brief Summary:
Menisci are crescent-shaped cartilage structures that are fundamentally important for the biomechanics and physiology of the knee joint They play a primary role in load transmission assist the ligaments in ensuring knee stability and thus protect against the onset of knee osteoarthritis Meniscal injuries are the most frequently encountered joint pathology and can cause pain mechanical blocks and recurrent effusions The treatment of these injuries has progressively evolved from meniscectomy removal of damaged meniscal tissue to the use of meniscal sutures where possible to allow the preservation of the greatest amount of meniscus numerous studies have shown a correlation between the amount of meniscus removed and the future onset of osteoarthritis Hutchinson AJSM 2014 Harston KSSTA 2012
However in some cases especially in the presence of complex andor chronic lesions meniscectomy remains the only viable surgical solution even today Over time months or years later a subgroup of patients experiences symptoms such as pain joint swelling and mechanical overload of the compartment subjected to meniscectomy a condition known as post-meniscectomy syndrome Some of these patients will subsequently develop knee osteoarthritis requiring invasive interventions such as partial or total knee replacement
Meniscal allograft transplantation MAT represents a valid therapeutic option for post-meniscectomy syndrome This procedure aims to restore joint functionality and stability through the transplantation of a meniscus from a cadaver donor MAT has been widely adopted in clinical practice showing success in reducing pain and improving joint functionality
Current studies suggest that meniscal transplantation can offer significant protection against osteoarthritis but the duration of this preventive effect is not yet fully understood Furthermore there are no studies that can demonstrate the state of osteoarthritis with radiographic controls pre- and post-treatment at a follow-up of over 15 years
However in some cases especially in the presence of complex andor chronic lesions meniscectomy remains the only viable surgical solution even today Over time months or years later a subgroup of patients experiences symptoms such as pain joint swelling and mechanical overload of the compartment subjected to meniscectomy a condition known as post-meniscectomy syndrome Some of these patients will subsequently develop knee osteoarthritis requiring invasive interventions such as partial or total knee replacement
Meniscal allograft transplantation MAT represents a valid therapeutic option for post-meniscectomy syndrome This procedure aims to restore joint functionality and stability through the transplantation of a meniscus from a cadaver donor MAT has been widely adopted in clinical practice showing success in reducing pain and improving joint functionality
Current studies suggest that meniscal transplantation can offer significant protection against osteoarthritis but the duration of this preventive effect is not yet fully understood Furthermore there are no studies that can demonstrate the state of osteoarthritis with radiographic controls pre- and post-treatment at a follow-up of over 15 years
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None