Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06522074
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Evaluating the Role of IGF-1 and S-Klotho in Plaque Phenotype
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluating the Role of IGF-1 and S-Klotho in Plaque Phenotype and Vulnerability The VISION Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VISION
Brief Summary:
BackgroundInsulin-like growth factor 1 IGF-1 is the primary peripheral mediator of growth hormone GH and has pleiotropic effects on development differentiation metabolism and cell survival Several in vivo and in vitro studies suggest that IGF-1 may have a protective effect on atherosclerosis as it suppresses macrophage recruitment and activation cytokine production and extracellular matrix degradation while promoting smooth muscle cell migration and proliferation and extracellular matrix deposition The protein sKlotho appears to be closely related to the GH-IGF-1 axis and some animal and in vitro studies hypothesize its protective role in the cardiovascular system Hypothesis The GH-IGF-1 axis and sKlotho influence mechanisms determining coronary atherosclerosis Circulating levels of IGF-1 and sKlotho may correlate with the morphology of atherosclerotic plaques and particularly with the vulnerability of coronary lesions
Objectives To evaluate the correlation between atherosclerotic plaque phenotype and the GH-IGF-
1 axis and sKlotho in patients with chronic coronary syndrome using intravascular imaging with Optical Coherence Tomography OCT MethodsAll patients with chronic coronary syndrome who meet the inclusion and exclusion criteria and undergo coronary angiography and intravascular imaging with optical coherence tomography will be included At the end of the procedure a blood sample will be taken to measure IGF-1 sKlotho and GH receptor GHR polymorphism
Objectives To evaluate the correlation between atherosclerotic plaque phenotype and the GH-IGF-
1 axis and sKlotho in patients with chronic coronary syndrome using intravascular imaging with Optical Coherence Tomography OCT MethodsAll patients with chronic coronary syndrome who meet the inclusion and exclusion criteria and undergo coronary angiography and intravascular imaging with optical coherence tomography will be included At the end of the procedure a blood sample will be taken to measure IGF-1 sKlotho and GH receptor GHR polymorphism
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None