Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06521684
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Translational Study of MSS TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Translational Study of MSS TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective is to understand the relationship between TP53 mutation MSS and chromosome instability in endometrial cancer and the effect on clinical prognosisWe will collect a small amount of tumor tissue samples NGS panel detection and WGDAS analysis were performed on the tissue Paracancer tissue was used as a negative control and relevant information in medical records during the operation Then we will collect clinical diagnosis and disease information through telephone follow-up after the completion of the operation
Detailed Description:
The test is sequenced using Illumina high-throughput sequencers and accompanying kits Conduct preliminary quality control on the samples and the tumor cell content of the tissue samples shall not be less than 30 Tissue DNA was extracted from tumor tissue samples according to the instructions of the QIAGEN DNA extraction kit Samples qualified for quality control shall be arranged for further library construction The extracted DNA samples were sequentially purified by fragment purification terminal repair splicing fragment size selection PCR amplification product purification library enrichment and library product quality control After qualified quality control the constructed library was sequenced by Illumina matching kit Bioinformatics analysis would be conducted
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None