Ignite Creation Date:
2024-10-26 @ 3:36 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06521359
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-22
Brief Title:
Role of Follicular T Cells in Hashimotos Thyroiditis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Role of Follicular Helper and Follicular Regulatory T Cells in Hashimotos Thyroiditis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Measure the frequency of Follicular helper Tcells and Follicular regulatory T cells in peripheral blood samples in Hashimotos pts in comparison with control
Detailed Description:
Hashimoto thyroiditis also known as chronic autoimmune thyroiditis and chronic lymphocytic thyroiditis is an autoimmune disease in which thyroid cells are destroyed via cell and antibody-mediated immune processes It is the most common cause of hypothyroidism in developed countries In contrast the most common cause of hypothyroidism worldwide is an inadequate dietary intake of iodine The pathophysiology of Hashimoto thyroiditis involves the formation of antithyroid antibodies that attack the thyroid tissue causing progressive fibrosis The diagnosis can be challenging and consequently the condition is sometimes not diagnosed until late in the disease process The most common laboratory findings demonstrate elevated thyroid-stimulating hormone TSH and low thyroxine T4 levels coupled with increased antithyroid peroxidase anti-TPO antibodies and antithyroglobulin anti-Tg antibodies
Recent years have shown that Hashimoto thyroiditis development depends on an immune defect in an individual with genetic susceptibility together with environmental factors
Recent years have shown that Hashimoto thyroiditis development depends on an immune defect in an individual with genetic susceptibility together with environmental factors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None