Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06514300
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-06-27
Brief Title:
Investigating Myosteatosis in Steatotic Liver Diseases
Sponsor:
None
Organization:
None
Study Overview
Official Title:
MYO-SLD a Prospective Study to Determine the Phenotype of Muscle Fat Accumulation in a Cohort of Patients With SLD as to Confirm the Association Between Muscle Composition and Texture and the Phenotype of Liver Disease
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MYO-SLD
Brief Summary:
Steatotic liver diseases SLD are the most common chronic liver diseases worldwide SLD are defined by an excessive liver lipid content steatosis of more than 5 of the total liver weight and includes 3 clinical entities metabolic dysfunction-associated steatotic liver disease MASLD alcohol-related liver disease ALD and a mixed entity combining the two settings referred as MetALD SLD are associated to extra-hepatic complications such as cardiovascular diseases insulin resistance or muscle changes Among the latter myosteatosis defined by an excessive muscle fat content has been reported as a muscle change in MASLD occuring even in non-cirrhotic stages Investigators will explore these muscle changes in SLD patients according to the severity of the underneath liver disease
Detailed Description:
This project investigates the correlation between liver and muscle phenotypes assessed in a cohort of all 3 SLD subgroups MASLD ALD and MetALD If a severe form of SLD is suspected based on a severely increased liver elasticity assessed by transient elastography participants undergo a liver biopsy liver and muscle magnetic resonance imaging Eating habits and physical activity level are recorded using the 24 hour-recall and international physical activity questionnaire Psychological disorders are also screened using dedicated questionnaires
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None