Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06514209
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-16
Brief Title:
Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ARDS
Brief Summary:
Acute respiratory distress syndrome ARDS is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors leading to refractory hypoxemia It has high incidence and mortality rates Neuromuscular blocking agents NMBAs play a crucial role as adjunctive therapy for ARDS aiding in lung-protective ventilation by inhibiting excessive spontaneous breathing improving patient-ventilator synchrony and reducing barotrauma
Determining the appropriate depth of muscle relaxation in moderate to severe ARDS patients receiving NMBAs remains a clinical challenge Research has shown that partial neuromuscular blockade is feasible in certain ARDS patients However large randomized controlled trials RCTs and clinical practices often use higher doses of NMBAs to ensure complete cessation of spontaneous breathing This indicates an ongoing debate regarding the optimal depth of neuromuscular blockade necessary for lung-protective ventilation in ARDS patients It also raises the question of whether the optimal depth of neuromuscular blockade varies among patients with different severities of ARDS
This study aims to investigate changes in respiratory mechanics and other physiological parameters in moderate to severe ARDS patients under different depths of neuromuscular blockade The investigators will evaluate the impact of targeted neuromuscular blockade depth on lung protection in these patients
Determining the appropriate depth of muscle relaxation in moderate to severe ARDS patients receiving NMBAs remains a clinical challenge Research has shown that partial neuromuscular blockade is feasible in certain ARDS patients However large randomized controlled trials RCTs and clinical practices often use higher doses of NMBAs to ensure complete cessation of spontaneous breathing This indicates an ongoing debate regarding the optimal depth of neuromuscular blockade necessary for lung-protective ventilation in ARDS patients It also raises the question of whether the optimal depth of neuromuscular blockade varies among patients with different severities of ARDS
This study aims to investigate changes in respiratory mechanics and other physiological parameters in moderate to severe ARDS patients under different depths of neuromuscular blockade The investigators will evaluate the impact of targeted neuromuscular blockade depth on lung protection in these patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None