Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06513520
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-07-16
Brief Title:
Evaluation of Monocyte Expression of HLA-DR mHLA-DR in Geriatric Service
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluation of Monocyte Expression of HLA-DR mHLA-DR in the Multi-pathological Elderly Subject in Geriatric Service
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SENIOR HLA DR
Brief Summary:
The acceleration of population aging and the improved management of comorbidities lead to an increase in the number of multi-pathological elderly patients admitted to geriatric services This is an extremely specific population in terms of immunology due to the presence of immunosenescence physiological aging of the immune system and the potential additional effect of multiple chronic pathologies comorbidities presented by these patients
The specific effect of multiple chronic pathologies on the immune status of elderly patients is currently underexplored because most studies on immune system aging only include elderly patients who do not have comorbidities or treatments that could impact the immune system eg SENIEUR protocol Therefore their results are not applicable to patients in geriatric services
The decrease in monocyte expression of HLA-DR mHLA-DR has been studied as a marker of immune alteration in intensive care units in the context of sepsis but also in chronic pathologies eg cancer diabetes renal insufficiency These chronic pathologies are frequently found in elderly subjects
The objective of the study would therefore be to investigate the relative contribution of age immunosenescence and comorbidities to the alteration of the immune status of geriatric patients through the measurement of mHLA-DR
To date no study has explored mHLA-DR in a population of multi-pathological geriatric patients Our work aims to generate initial data through a pilot study in hospitalized multi-pathological subjects over 75 years old in geriatric services
The specific effect of multiple chronic pathologies on the immune status of elderly patients is currently underexplored because most studies on immune system aging only include elderly patients who do not have comorbidities or treatments that could impact the immune system eg SENIEUR protocol Therefore their results are not applicable to patients in geriatric services
The decrease in monocyte expression of HLA-DR mHLA-DR has been studied as a marker of immune alteration in intensive care units in the context of sepsis but also in chronic pathologies eg cancer diabetes renal insufficiency These chronic pathologies are frequently found in elderly subjects
The objective of the study would therefore be to investigate the relative contribution of age immunosenescence and comorbidities to the alteration of the immune status of geriatric patients through the measurement of mHLA-DR
To date no study has explored mHLA-DR in a population of multi-pathological geriatric patients Our work aims to generate initial data through a pilot study in hospitalized multi-pathological subjects over 75 years old in geriatric services
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None