Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06513416
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-17
Brief Title:
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Gut Microbiota and Pulmonary Complications After Non Cardiac Elective Surgery in Elderly Patients
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study adopts a combination of retrospective and prospective cohort research methods to explore the composition of preoperative oropharyngeal and gut microbiota in elderly patients undergoing elective upper abdominal surgery aiming to analyze the correlation between preoperative oropharyngeal and intestinal microbiota composition and metabolite levels and the occurrence of postoperative pulmonary complications PPCs The research subjects of the retrospective cohort study were participants ClinicalTrialsgov No NCT05679661 included in the prospective RCT on the effects of perioperative immune nutrition intervention and oral hygiene on postoperative complications in elderly patients which was conducted at Peking Union Medical College Hospital from January 2023 to present The prospective cohort study plans to continue enrolling elderly patients aged 65 who underwent elective upper abdominal surgery
This study collects preoperative oropharyngeal and fecal samples as well as preoperative plasma from patients for microbial sequencing and untargeted metabolomics analysis The main outcome measurement is PPCs which include pneumonia atelectasis and hypoxemia within 7 days after surgery Inflammatory cells and cytokines in peripheral blood are secondary outcomes
This study collects preoperative oropharyngeal and fecal samples as well as preoperative plasma from patients for microbial sequencing and untargeted metabolomics analysis The main outcome measurement is PPCs which include pneumonia atelectasis and hypoxemia within 7 days after surgery Inflammatory cells and cytokines in peripheral blood are secondary outcomes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None