Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06512376
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-07-16
Brief Title:
Hereditary Cerebral Small Vessel Diseases Registry-Trial Ready Cohort
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Hereditary Cerebral Small Vessel Diseases Registry-Trial Ready Cohort HCSVD-TRC
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HCSVD-TRC
Brief Summary:
We took hereditary cerebral small vessel disease hCSVD patients as our main subjects aiming to establish a platform for a comprehensive evaluation and long-term follow-up Deeply explore the pathophysiological mechanism of hCSVD which may render the theoretical basis for the treatment and management of hCSVD
Detailed Description:
Cerebral Small Vessel Disease is a series of clinical imaging and pathological syndromes caused by a variety of risk factors affecting cerebral arterioles arterioles capillaries and venules accounting for 20 of stroke and 45 of dementia
Although the incidence rate of hereditary small cerebral vascular disease is low because of its early onset high disability rate and lack of effective treatment it also brings a heavy burden to the patients and their families Therefore it is important to study the pathogenic gene pathogenesis clinical characteristics and imaging manifestations of hereditary cerebrovascular disease to provide a theoretical basis for the treatment and prevention of hereditary cerebrovascular disease in the future
This multi-center prospective continuous registry study runs from 2022 to 2027 The study is expected to recruit 100 subjects according to the sample size design of the registry study
We recruited patients with the hereditary cerebral small-vessel disease hCSVD intending to establish a platform for a comprehensive assessment and long-term follow-up by collecting genetics imaging and clinical symptoms of the primary disease and its relatives With long-term follow-up of the development and prognosis of imaging and clinical symptoms combined with genetics we will work on the correlation between genes and phenotype and deeply explore the pathophysiological mechanism of hCSVD which may render the theoretical basis for the treatment and management of hCSVD
Although the incidence rate of hereditary small cerebral vascular disease is low because of its early onset high disability rate and lack of effective treatment it also brings a heavy burden to the patients and their families Therefore it is important to study the pathogenic gene pathogenesis clinical characteristics and imaging manifestations of hereditary cerebrovascular disease to provide a theoretical basis for the treatment and prevention of hereditary cerebrovascular disease in the future
This multi-center prospective continuous registry study runs from 2022 to 2027 The study is expected to recruit 100 subjects according to the sample size design of the registry study
We recruited patients with the hereditary cerebral small-vessel disease hCSVD intending to establish a platform for a comprehensive assessment and long-term follow-up by collecting genetics imaging and clinical symptoms of the primary disease and its relatives With long-term follow-up of the development and prognosis of imaging and clinical symptoms combined with genetics we will work on the correlation between genes and phenotype and deeply explore the pathophysiological mechanism of hCSVD which may render the theoretical basis for the treatment and management of hCSVD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None