Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06506058
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-06-13
Brief Title:
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinsons Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinsons Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Currently there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD both with and without FOG This set of experiments has two primary purposes to 1 understand the pathological neurophysiology underlying freezing of gait FOG during movement transitions and FOG-inducing movements and 2 identify neurological biomarkers associated with FOG and FOG-inducing movements To achieve this the investigators will assess vestibular activity using the noninvasive neuromodulation technique of electrical vestibular stimulation EVS Experiments 1 and 2 and assess cortical activity by recording via electroencephalography EEG Experiments 3 and 4 no stimulation included These experiments will investigate the vestibular EVS Experiments and cortical EEG experiments contributions to movement transitions during standing walking turning and changing movement rates Upon completion of this project the investigators expect to provide a new understanding of key neural systems vestibular and cortical involved in the pathogenesis of movement impairment and freezing episodes during movement transitions including gait initiation turning and changing movement rates in people with PD An increased understanding of the temporal dynamics of systems involved in FOG and FOG-inducing movements could later guide the development and delivery of novel interventions eg closed-loop deep brain stimulation DBS or non-invasive brain stimulation to decrease the incidence and severity of FOG episodes reducing fall risk and morbidity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None