Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06505421
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-03
Brief Title:
Eccentric Exercise and Fatigue in Multiple Sclerosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effect of Lower Extremity Eccentric Resistance Training on Fatigue in Multiple Sclerosis
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis MS The primary question this study is asking is the following is eccentric resistance training more fatiguing than traditional resistance training in persons with MS Participants will be asked to come for two sessions for two weeks In the first week subjects will undergo a bout of either traditional or eccentric resistance training The next day they will return to assess their level of fatigue The following week the subject will return and undergo whatever type of training they did not experience the first week and its effects on fatigue will again be assessed The difference between the subjects level of fatigue for either condition will be compared
Detailed Description:
Persons with multiple sclerosis MS have mobility deficits Exercise is commonly used to treat these mobility deficits but must be done so judiciously in order to limit the effects of fatigue one of the most common disease findings In persons with MS fatigue can limit the amount of exercise performed Eccentric training where a muscle is lengthened under resistance has been shown to produce greater gains in strength with less energy expenditure when compared to traditional strength training where a muscle is both lengthened and shortened under resistance However eccentric strength training has been shown to result in delayed onset muscle soreness which may also limit how much exercise a person with MS can perform The purpose of the study is to compare the impact of eccentric versus traditional strength training programs on fatigue and persons with multiple sclerosis The hypothesis is that there will be no difference in fatigue measurements between the two conditions If the hypothesis is correct it will suggest that eccentric training should be the subject of further study to assess its feasibility and effectiveness in treating mobility deficits in person with multiple sclerosis
A randomized crossover design will be used Ambulatory participants with a diagnosis of MS will be randomized into either a eccentric or traditional training condition Each training condition will consist of a single session of training The following day the patient will return and their levels of fatigue assessed The next week the subjects will return and crossover undergoing whatever type of training they did not experience in the previous week and the impact of the training will again be assessed
A randomized crossover design will be used Ambulatory participants with a diagnosis of MS will be randomized into either a eccentric or traditional training condition Each training condition will consist of a single session of training The following day the patient will return and their levels of fatigue assessed The next week the subjects will return and crossover undergoing whatever type of training they did not experience in the previous week and the impact of the training will again be assessed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None