Ignite Creation Date:
2024-10-26 @ 3:35 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06505135
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
Stem Cell Treatment for Regeneration of the Rotator Cuff Lipo-Cuff Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Stem Cell Treatment for Regeneration of the Rotator Cuff Lipo-Cuff Study
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Treatment of rotator cuff tears with micro-fragmented adipose tissue is a minimal-invasive procedure with the potential to shorten and ease recovery accelerate return to daily activity and work of thus with a potential capacity to improve the functional result compared to conventional surgery alone The study will provide evidence whether the addition of micro-fragmented adipose tissue therapy can augment conventional rotator cuff tear treatment The study will also reveal whether this treatment can be feasible for standard care of patients with rotator cuff tear as it will be simple to standardize Moreover besides providing a novel treatment for patients with rotator cuff tears the project will based on data from muscle biopsies and scanning modalities generate new knowledge preparing for precision regenerative medicine in shoulder disease
Detailed Description:
Damage to the tendons that stabilize the shoulder particularly the supraspinatus tendon tear has been recognized as the key lesion in rotator cuff tears However the lack of full functional recovery after surgical tendon reconstruction suggests that additional changes in the tissue are obstacles to rehabilitation Recent studies demonstrate pathological changes in the supraspinatus muscle in animal models as a consequence of tendon tear The muscle pathology includes muscle fibre atrophy intracellular lipid accumulation mitochondrial dysfunction fibril disorganization and reduced regenerative capacity Moreover fibrosis accumulation of adipocytes and inflammation develop in these muscles Muscle strength is decreased by 30 several months after rotator cuff tear repair Thus the muscle becomes weaker and stiffer despite repair suggesting that treatment of rotator cuff tear should include managing cuff muscle dysfunction
Adipose derived cell therapy Muscle regeneration occurs in a specific environment to which several cell types contribute The resident stem cell in skeletal muscle is the satellite cell When skeletal muscle is damaged the satellite cells are activated and start to proliferate to muscle repairing myoblast Additional cell types support the regeneration by modulating the myoblast response inflammation and vascularization Skeletal muscle harbours a mesenchymal cell the Fibro-Adipogenic Progenitor FAP cell We have shown that FAPs respond to muscle damage and is part of the muscle stem cell niche with supportive functions in muscle regeneration This makes the use of FAPs or mesenchymal cells with a similar function derived from fat an interesting approach for muscle repair
Implantation of various preparations of cell material that contain Mesenchymal Stromal Cells MSC have been used as therapy in a wide range of disorders including lesions in cardiac muscle The most common sources of cells have been the bone marrow and adipose tissue and the preparations have ranged from crude isolates of mononuclear cells eg total stromal cells to more homogenous cultured cell isolates that mainly contain MSC Although these mesenchymal cells are able to differentiate into tissues such as bone and fat18 their major implication in tissue repair appears to be a capacity to support the regenerative milieu Their known capacities include stimulation of tissue-specific cells like the myogenic cells induction of vessel growth and regulation of inflammation and apoptosis Cells extracted from adipose tissue cells have shown a regenerative effect without major adverse effects when used as therapy in a range of tissue Compared to skeletal muscle it is easier and less traumatic to obtain regenerative cells in a sufficient quantum from adipose tissue
Production of cell preparations exclusively consisting of MSC requires isolation procedures and culturing for weeks all of which has to be performed in certified laboratories In case of homolog transplantation the patient will have to have tissue harvested weeks before the operation However cell preparations enriched with MSC can be manufactured with simple physical treatment of aspirated adipose tissue in a closed system This can take place in the operation theatre within an hour This means that the preparation can be performed the same day as the implantation shall take place in connection with the main operation
The adipose tissue will be processed with cutting grinding and filtering - not to be considered as substantial manipulation Likewise the expected functions of the implanted active cells in muscle are also found in adipose tissue which is why the material probably not should be considered as engineered
The material is derived from adipose tissue and will be used in skeletal muscle and the use can in this respect be considered non-homologous However as the expected major functions in skeletal muscle are the same as in adipose tissue the function may be accepted as homologous
Therefore this trial treats patients in a one-day procedure The adipose tissue will be harvested and processed as an initial procedure during surgery At the end of the tendon suture procedure the MSC enriched fragmented tissue will be injected into the supraspinatus muscle
Adipose derived cell therapy Muscle regeneration occurs in a specific environment to which several cell types contribute The resident stem cell in skeletal muscle is the satellite cell When skeletal muscle is damaged the satellite cells are activated and start to proliferate to muscle repairing myoblast Additional cell types support the regeneration by modulating the myoblast response inflammation and vascularization Skeletal muscle harbours a mesenchymal cell the Fibro-Adipogenic Progenitor FAP cell We have shown that FAPs respond to muscle damage and is part of the muscle stem cell niche with supportive functions in muscle regeneration This makes the use of FAPs or mesenchymal cells with a similar function derived from fat an interesting approach for muscle repair
Implantation of various preparations of cell material that contain Mesenchymal Stromal Cells MSC have been used as therapy in a wide range of disorders including lesions in cardiac muscle The most common sources of cells have been the bone marrow and adipose tissue and the preparations have ranged from crude isolates of mononuclear cells eg total stromal cells to more homogenous cultured cell isolates that mainly contain MSC Although these mesenchymal cells are able to differentiate into tissues such as bone and fat18 their major implication in tissue repair appears to be a capacity to support the regenerative milieu Their known capacities include stimulation of tissue-specific cells like the myogenic cells induction of vessel growth and regulation of inflammation and apoptosis Cells extracted from adipose tissue cells have shown a regenerative effect without major adverse effects when used as therapy in a range of tissue Compared to skeletal muscle it is easier and less traumatic to obtain regenerative cells in a sufficient quantum from adipose tissue
Production of cell preparations exclusively consisting of MSC requires isolation procedures and culturing for weeks all of which has to be performed in certified laboratories In case of homolog transplantation the patient will have to have tissue harvested weeks before the operation However cell preparations enriched with MSC can be manufactured with simple physical treatment of aspirated adipose tissue in a closed system This can take place in the operation theatre within an hour This means that the preparation can be performed the same day as the implantation shall take place in connection with the main operation
The adipose tissue will be processed with cutting grinding and filtering - not to be considered as substantial manipulation Likewise the expected functions of the implanted active cells in muscle are also found in adipose tissue which is why the material probably not should be considered as engineered
The material is derived from adipose tissue and will be used in skeletal muscle and the use can in this respect be considered non-homologous However as the expected major functions in skeletal muscle are the same as in adipose tissue the function may be accepted as homologous
Therefore this trial treats patients in a one-day procedure The adipose tissue will be harvested and processed as an initial procedure during surgery At the end of the tendon suture procedure the MSC enriched fragmented tissue will be injected into the supraspinatus muscle
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None