Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005309
Status:
COMPLETED
Last Update Posted:
2018-12-14
First Post:
2000-05-25
Brief Title:
Prospective Study of HIV Infection in Hemophiliacs
Sponsor:
Bloodworks
Organization:
Bloodworks
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs
Detailed Description:
BACKGROUND
In the late 1980s hemophiliacs were transfused with a variety of blood products including large amounts of cryoprecipitate In comparison to other cohorts hemophiliacs are CMV- resulting in a comparison group for the study of this virus as a potential cofactor In contrast non A non-B hepatitis is common in comparison to other cohorts and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection
DESIGN NARRATIVE
Disease-free survival rates were determined in HIV-infected hemophiliacs The effects of co-factors such as intensive transfusion concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained Host-virus interaction was assessed through the use of plasma cultures specific antibody titers and markers of immune changes detected by flow cytometry and immune function assays The immunology of asymptomatic stable infection was investigated The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored
In the late 1980s hemophiliacs were transfused with a variety of blood products including large amounts of cryoprecipitate In comparison to other cohorts hemophiliacs are CMV- resulting in a comparison group for the study of this virus as a potential cofactor In contrast non A non-B hepatitis is common in comparison to other cohorts and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection
DESIGN NARRATIVE
Disease-free survival rates were determined in HIV-infected hemophiliacs The effects of co-factors such as intensive transfusion concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained Host-virus interaction was assessed through the use of plasma cultures specific antibody titers and markers of immune changes detected by flow cytometry and immune function assays The immunology of asymptomatic stable infection was investigated The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL043512 | NIH | None | httpsreporternihgovquickSearchR01HL043512 |