Ignite Creation Date:
2024-10-25 @ 8:06 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06626412
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-01
Brief Title:
Longitudinal SV2A and MRI in Premanifest HD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Longitudinal Imaging of Striatal Synaptic Density and Volume in People with Premanifest Huntingtons Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
AIM to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD
DESIGN The investigators will include late premanifest HD mutations carriers and matched healthy controls All subjects will undergo a clinical examination with comprehensive assessment of motor and non-motor symptoms and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years
DESIGN The investigators will include late premanifest HD mutations carriers and matched healthy controls All subjects will undergo a clinical examination with comprehensive assessment of motor and non-motor symptoms and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None