Ignite Creation Date:
2024-10-25 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06586372
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-04
Brief Title:
CRPCRPAlb Ratio NL Ratio in Predictors of Both Systemic Infection and Survival in Patient with Sepsis in Assiut University Hospitals
Sponsor:
None
Organization:
None
Study Overview
Official Title:
CRPCRPAlb Ratio NL Ratio in Predictors of Both Systemic Infection and Survival in Patient with Sepsis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
the goal of this study is to asses the value of biomarker CRP CRPAlb ratio NL ratio in predictor of the outcome in normotensive patients with sepsis
The main question it aims to answer is
Does biomarker CRP CRPAlb ratio NL ratio can predict the outcome in patients with sepsis
The main question it aims to answer is
Does biomarker CRP CRPAlb ratio NL ratio can predict the outcome in patients with sepsis
Detailed Description:
Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection and it probably represents a pattern of response by the immune system to injury A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is susceptible to nosocomial infection
A biomarker describes a measurable indicator of a patient39s clinical condition that can be measured accurately and reproducibly Biomarkers offer utility for diagnosis prognosis early disease recognition risk stratification appropriate treatment theranostics and trial enrichment for patients with sepsis or suspected sepsis C-reactive protein CRP is an acute-phase protein that is produced following stimulation by various cytokines in response to infection ischemia trauma and other inflammatory conditions High CRP levels have been studied in relation to prognosis and mortality in critically ill patients On the other hand low serum albumin is known to be associated with poor prognosis and mortality Based on this knowledge we speculated that the ratio of CRP to albumin could be used as a predictive marker for mortality
Recently the CRPalbumin ratio a combination of markers for systemic inflammation and nutritional status has been extensively studied as an independent prognostic marker in patients with infection malignancy and other diseases However there are relatively few studies conducted focusing on critical care patients in the ICU Among the plethora of biomarkers available to clinicians investigating septic patients in the Emergency Department ED white blood cell count WBC are always taken into consideration due to their availability and low cost Serial measurement of RP is useful for clinicians decision-making as its serum levels correlate with the syndrome evo-lution Neutrophil-to-lymphocyte ratio NLR calculated from the complete blood count seems to be a reasonable tool for assessment during the sepsis course 8 9
A biomarker describes a measurable indicator of a patient39s clinical condition that can be measured accurately and reproducibly Biomarkers offer utility for diagnosis prognosis early disease recognition risk stratification appropriate treatment theranostics and trial enrichment for patients with sepsis or suspected sepsis C-reactive protein CRP is an acute-phase protein that is produced following stimulation by various cytokines in response to infection ischemia trauma and other inflammatory conditions High CRP levels have been studied in relation to prognosis and mortality in critically ill patients On the other hand low serum albumin is known to be associated with poor prognosis and mortality Based on this knowledge we speculated that the ratio of CRP to albumin could be used as a predictive marker for mortality
Recently the CRPalbumin ratio a combination of markers for systemic inflammation and nutritional status has been extensively studied as an independent prognostic marker in patients with infection malignancy and other diseases However there are relatively few studies conducted focusing on critical care patients in the ICU Among the plethora of biomarkers available to clinicians investigating septic patients in the Emergency Department ED white blood cell count WBC are always taken into consideration due to their availability and low cost Serial measurement of RP is useful for clinicians decision-making as its serum levels correlate with the syndrome evo-lution Neutrophil-to-lymphocyte ratio NLR calculated from the complete blood count seems to be a reasonable tool for assessment during the sepsis course 8 9
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None