Ignite Creation Date:
2024-10-25 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:36 PM
Study NCT ID:
NCT06533982
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-19
Brief Title:
Effect of Different Exercise Modalities on Cardiovascular and Cognitive Response in Postmenopausal Women
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Different Exercise Modalities on Cardiovascular and Cognitive Response in Postmenopausal Women With and Without Vasomotor Symptoms
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
WOMEN-EX-MOD
Brief Summary:
Menopause is a natural stage in female aging increasing cardiometabolic risk and making cardio-neuro-vascular disease CNVD the leading cause of mortality in women over 60 Declining ovarian hormones are linked to changes in body composition increased blood pressure and mild cognitive impairment Menopause also often involves significant symptoms like menopausal vasomotor symptoms VMS affecting 60-80 of women for 5-10 years Women with VMS exhibit a worse cardiovascular profile and greater cognitive decline
Physical exercise is a promising non-pharmacological option to reduce CNVD risk and limit cognitive impairment in postmenopausal women who have a 10-year window post-menopause during which physical activity benefits vascular and possibly neurovascular health Studies link physical activity to lower cognitive decline and improved quality of life However optimal exercise modalities for managing CNVD risk in postmenopausal women remain undetermined
Physical exercise is a promising non-pharmacological option to reduce CNVD risk and limit cognitive impairment in postmenopausal women who have a 10-year window post-menopause during which physical activity benefits vascular and possibly neurovascular health Studies link physical activity to lower cognitive decline and improved quality of life However optimal exercise modalities for managing CNVD risk in postmenopausal women remain undetermined
Detailed Description:
Menopause is a natural stage in the female aging process resulting in increased cardiometabolic risk making cardio-neuro-vascular disease CNVD the leading cause of female mortality worldwide after the age of 60 Indeed falling ovarian hormone concentrations are associated with altered body composition increased blood pressure as well as mild cognitive impairment
For some women menopause is also accompanied by symptoms that have a significant impact on their quality of life Among these menopausal vasomotor symptoms VMS - hot flushes night sweats are the most frequent affecting 60 to 80 of women for an average of 5 to 10 years Several studies have highlighted an altered cardiovascular profile dyslipidemia insulin resistance pre-hypertensionhypertension and a more marked decline in cognitive performance in women with VMS
In order to reduce the risk of CNVD and limit cognitive impairment physical exercise appears to be a particularly interesting non-pharmacological management option for postmenopausal women Indeed the latter seem to present a 10-year post-menopausal time window during which physical activity has a positive vascular and probably neurovascular effect although the latter remains to be demonstrated Numerous studies have also shown that physical activity is associated with a lower rate of cognitive decline and improved quality of life
However to date there is little evidence to determine which exercise modalities are most effective in managing the risk of CNVD in postmenopausal women
The aims of this study
To examine the effect of exercise on markers of cardio-neuro-vascular health and cognition in postmenopausal women
Second to compare the differences in the cardio-neuro-vascular and cognitive response to exercise dependent on the type of exercise the physical fitness and the presence of menopausal symptoms
Third to examine the effect of menopausal symptoms and physical fitness on cardio-neuro-vascular health markers and cognitive health markers
For some women menopause is also accompanied by symptoms that have a significant impact on their quality of life Among these menopausal vasomotor symptoms VMS - hot flushes night sweats are the most frequent affecting 60 to 80 of women for an average of 5 to 10 years Several studies have highlighted an altered cardiovascular profile dyslipidemia insulin resistance pre-hypertensionhypertension and a more marked decline in cognitive performance in women with VMS
In order to reduce the risk of CNVD and limit cognitive impairment physical exercise appears to be a particularly interesting non-pharmacological management option for postmenopausal women Indeed the latter seem to present a 10-year post-menopausal time window during which physical activity has a positive vascular and probably neurovascular effect although the latter remains to be demonstrated Numerous studies have also shown that physical activity is associated with a lower rate of cognitive decline and improved quality of life
However to date there is little evidence to determine which exercise modalities are most effective in managing the risk of CNVD in postmenopausal women
The aims of this study
To examine the effect of exercise on markers of cardio-neuro-vascular health and cognition in postmenopausal women
Second to compare the differences in the cardio-neuro-vascular and cognitive response to exercise dependent on the type of exercise the physical fitness and the presence of menopausal symptoms
Third to examine the effect of menopausal symptoms and physical fitness on cardio-neuro-vascular health markers and cognitive health markers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None