Ignite Creation Date:
2024-10-25 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06519201
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-16
Brief Title:
Effectiveness and Safety of SpineCare Used in Conjunction With Spinal Realignment Therapy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effectiveness and Safety of SpineCare Used in Conjunction With Spinal Realignment Therapy in the Treatment of Idiopathic Scoliosis An Investigator-initiated Randomized Single-blind Pilot Study
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to evaluate the safety and effectiveness of traction treatment using SpineCare Device
Research period May 1 2023 - November 30 2023 7 months
Research subjects
Malefemale between 19 and 70 years old
Scoliosis patients Scoliosis patients whose Cobbs angle is less than 1539
Treatment method Group that applied traction treatment using SpineCare traction device and group that applied traction treatment without using SpineCare traction device
Treatment period Treatment twice a week from the 1st to 3rd week from the start of treatment treatment once a week from the 4th to 7th week A total of 10 times takes approximately 2 months
Treatment time approximately 50 minutes
Research period May 1 2023 - November 30 2023 7 months
Research subjects
Malefemale between 19 and 70 years old
Scoliosis patients Scoliosis patients whose Cobbs angle is less than 1539
Treatment method Group that applied traction treatment using SpineCare traction device and group that applied traction treatment without using SpineCare traction device
Treatment period Treatment twice a week from the 1st to 3rd week from the start of treatment treatment once a week from the 4th to 7th week A total of 10 times takes approximately 2 months
Treatment time approximately 50 minutes
Detailed Description:
1 Introduction Idiopathic scoliosis IS is a condition characterized by an abnormal lateral curvature and rotational deformity of the vertebral column typically presenting as either an S- or C-shaped curve in the vertebral column IS leads to musculoskeletal asymmetry culminating in morphological and geometric changes in the torso It can result in numerous is-sues such as changes in posture sensory impairment balance and gait problems limitations in physical activity pain body image disturbances and challenges in social communication The treatment approach for IS depends on the severity of the curve measured by Cobbs angle surgical intervention is considered for angles of 40º or greater while non-surgical treatments are considered for angles under 40º Non-surgical modalities include physical therapy manipulative therapy braces and exercise therapy Traditionally braces are recommended for Cobbs angles of 20-40º However braces often lead to undesirable effects such as psychological stress discomfort in daily activities negative selfesteem and impaired respiratory function and their effectiveness remains controversial Manipulative therapy aims to correct the alignment of spinal segments and optimize the mechanical interaction between the spine and torso to facilitate healing and restore spinal mobility Therefore manipulative therapy focusing on correcting the position of spinal segments and improving neuromuscular stabilization is needed to manage IS 9 Such treatments include chiropractic therapy Chuna manual therapy CMT and spinal realignment therapy SRT
The difference among these three treatment modalities is the patients posture during treatment During chiropractic treatment or CMT the patient lies in the supine or prone position During SRT the patient lies in the prone position and the lower extremities are placed under traction against gravity using SpineCare SpineCare Korea Dr Bom Co Ltd is a modernized traction device inspired by Panseo 攀索 which was introduced in the section on external therapy techniques 正骨心法要旨 in Yizong Jinjian a medical treatise compiled by Wu Jia 吳假 and others during the Qing Dynasty This contraption received medical device certification from the Korean Ministry of Food and Drug Safety in 2020 License No 20-5054 The SpineCare device is used by having the patient lying prone with knees bent at 90º and both ankles secured on ankle braces to pull them up-wards against gravity This posture helps create space between spinal segments allowing deformed spinal and skeletal structures to return to their normal positions With-out SpineCare spinal imbalance may not be adequately addressed and corrected Administering corrective treatment without spinal segment spacing may actually decrease spacing increase pressure between the discs and vertebrae and exacerbate disc abnormalities Furthermore it may affect the adjacent muscles and ligaments thereby increasing pain and restricting movement and function which in turn could cause discomfort and limitations in performing the activities of daily living Thus ensuring adequate space be-tween spinal segments using SpineCare is crucial for restoring the normal positions of the spine and skeletal structures
However research on the effectiveness of SRT using SpineCare is insufficient There-fore this study aimed to assess the effectiveness and safety of the application of SRT in conjunction with SpineCare in patients with IS In this study we will elaborate on the specific procedures involved in SRT with SpineCare for patients with IS and report the out-comes using NRS and Cobbs angle
2 Materials and Methods 21 Study Design and Setting This investigator-initiated randomized controlled single-blind trial was approved by the Institutional Review Board Date of approval Rebom Clinic June 1 2023 Written informed consent was obtained from all patients before trial commencement
22 Participants Participants were enrolled from among the patients of Rebom Clinic from June 1 to November 30 2023 by posting a recruitment announcement within the clinic The inclusion criteria were age ranging from 19-70 years and spinal radiographs obtained in an upright position Patients with a Cobbs angle of 15-39º on X-rays who consented to participate in the trial were included The exclusion criteria were spine-related surgery in the past six months diagnosis of osteoporosis history of other non-surgical treatments participation in another interventional clinical trial in the past month including human studies and plan to participate in another interventional study after starting this trial
23 Randomization and Allocation Concealment The investigator responsible for data analysis prepared two envelopes marked with odd and even numbers Participants chose an envelope in the order of arrival To maintain a 11 ratio between the trial and control groups participants were assigned to the remaining group once one group reached capacity Participants who chose an odd number were assigned to the SpineCare based SRT group trial group TG and those who chose an even number were assigned to the SRT group without SpineCare control group CG
24 Outcomes 241 Primary Outcome Measure The primary outcome was the Numerical Rating Scale NRS score which was used to quantify the subjective pain experienced by the patient over the past week Patients selected a number that best reflected their pain intensity where 0 indicates no pain and 10 represents extreme pain with higher values indicating greater severity of pain There is consensus that the NRS has greater validity and intensity compared to other instruments The Pearson correlation coefficient r 093 indicating the correlation be-tween the NRS and Visual Analog Scale indicates robust validity and reliability
242 Secondary Outcome Measures The secondary outcome measure was Cobbs angle which is typically used to assess the severity of scoliosis Cobbs angle is defined as the angle between a line parallel to the upper border of the upper vertebra and a line parallel to the lower border of the lowermost vertebra of the lateral curvature of the spine The inter-rater and intrarater reliability coefficients for measuring Cobbs angle are 0970 and 0969 respectively
243 Safety Adverse events were monitored through patient interviews before and after treatment Participants were also instructed to notify the medical team by phone any time upon occurrence of an adverse event
25 Interventions Korean medicine doctors performed the treatment regimens for both groups The TG underwent SRT with SpineCare while the CG underwent SRT without SpineCare Treat-ment was administered for six consecutive weeks with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks No additional treatments eg procedures or surgeries were allowed during the six-week period To analyze pain according to the number of treatment sessions a counselor assessed patients using the NRS after each of the ten treatment sessions To compare the differences in Cobbs angle between the groups X-rays were performed after the first and tenth treatment sessions Detailed records of adverse events were maintained before and after each treat-ment session
251 Spinal Realignment Therapy SRT an original spinal alignment technique developed by the Society of Spinal Conduction Exercise and Manipulation functions as a diagnostic and manual therapeutic technique to promote balance and improve harmony in the human body In this study SRT was implemented in three steps
Step 1 entailed the application of traction With the patient lying on their side the practitioner grasps the leg on top at the dorsum and heel and slowly pulls it This motion slightly dislocates the femoral head from the hip joint allowing it to realign to its normal position thereby relieving deformities in the hip joint and tension in the surrounding muscles and soft tissues Next the patient lies prone with knees bent The ankles are then secured with SpineCares ankle braces and the knees are lifted slightly against gravity In this position the practitioner uses their hands or feet to apply frictional force pushing the sacrum towards the direction of the coccyx to correct the formers position
Step 2 entails the application of pressure and thrust This step treats pelvic imbalance while the patient is prone with the lower limbs lifted against gravity The practitioner places their hands or feet on the patients right and left iliac crests sacroiliac joints and sacrum using their body weight to exert pressure This process aims to correct any misa-lignment of the sacrum and sacroiliac joints as well as the imbalance of the left and right ilia
Step 3 entails securing the intervertebral space The practitioner addresses the im-balance in the thoracolumbar region while the patient remains prone with the lower limbs lifted against gravity The practitioner applies pressure sequentially to the patients deformed sacral spinous processes lumbar spinous processes and thoracic spinous pro-cesses using their hands or feet This technique aims to align the position of the sacrum the space between L5-S1 and the space between the facet joints and spinous processes of the lumbar and thoracic segments to their normal positions
252 SpineCare In the TG patients lay prone on the SpineCare mattress When patients bend their knees the practitioner secures both ankles in SpineCares ankle braces Next the legs are lifted against gravity to a height of 1-5 cm above the floor till a point that does not strain the patients pelvis based on the physicians judgment In this position steps 1-3 of the SRT are performed After treatment the legs are lowered to the floor using SpineCares ankle braces
The CG underwent steps 1-3 while lying prone on a regular therapy mattress
26 Statistical Analysis Statistical analyses were performed using SPSS 180 for Windows SPSS Inc Chicago IL USA NRS scores after each treatment session were compared sessions 1-10 Data between the TG and CG were compared using Wilcoxons signed-rank test and the Mann-Whitney U test The values of Cobbs angle at baseline session 1 and after the tenth treatment session were compared All data were presented as the mean standard devia-tion or number p-values 05 were deemed statistically significant Odds ratios were computed for comparison between the TG and CG including the main analysis and re-sults were deemed significant when the 95 confidence interval CI did not include 1 Adverse events were presented as frequencies and percentages and the chi-squared test or Fishers exact test Fishers exact test is used when more than 25 of the cells have an ex-pected frequency of less than 5 was used to compare the groups as needed
The difference among these three treatment modalities is the patients posture during treatment During chiropractic treatment or CMT the patient lies in the supine or prone position During SRT the patient lies in the prone position and the lower extremities are placed under traction against gravity using SpineCare SpineCare Korea Dr Bom Co Ltd is a modernized traction device inspired by Panseo 攀索 which was introduced in the section on external therapy techniques 正骨心法要旨 in Yizong Jinjian a medical treatise compiled by Wu Jia 吳假 and others during the Qing Dynasty This contraption received medical device certification from the Korean Ministry of Food and Drug Safety in 2020 License No 20-5054 The SpineCare device is used by having the patient lying prone with knees bent at 90º and both ankles secured on ankle braces to pull them up-wards against gravity This posture helps create space between spinal segments allowing deformed spinal and skeletal structures to return to their normal positions With-out SpineCare spinal imbalance may not be adequately addressed and corrected Administering corrective treatment without spinal segment spacing may actually decrease spacing increase pressure between the discs and vertebrae and exacerbate disc abnormalities Furthermore it may affect the adjacent muscles and ligaments thereby increasing pain and restricting movement and function which in turn could cause discomfort and limitations in performing the activities of daily living Thus ensuring adequate space be-tween spinal segments using SpineCare is crucial for restoring the normal positions of the spine and skeletal structures
However research on the effectiveness of SRT using SpineCare is insufficient There-fore this study aimed to assess the effectiveness and safety of the application of SRT in conjunction with SpineCare in patients with IS In this study we will elaborate on the specific procedures involved in SRT with SpineCare for patients with IS and report the out-comes using NRS and Cobbs angle
2 Materials and Methods 21 Study Design and Setting This investigator-initiated randomized controlled single-blind trial was approved by the Institutional Review Board Date of approval Rebom Clinic June 1 2023 Written informed consent was obtained from all patients before trial commencement
22 Participants Participants were enrolled from among the patients of Rebom Clinic from June 1 to November 30 2023 by posting a recruitment announcement within the clinic The inclusion criteria were age ranging from 19-70 years and spinal radiographs obtained in an upright position Patients with a Cobbs angle of 15-39º on X-rays who consented to participate in the trial were included The exclusion criteria were spine-related surgery in the past six months diagnosis of osteoporosis history of other non-surgical treatments participation in another interventional clinical trial in the past month including human studies and plan to participate in another interventional study after starting this trial
23 Randomization and Allocation Concealment The investigator responsible for data analysis prepared two envelopes marked with odd and even numbers Participants chose an envelope in the order of arrival To maintain a 11 ratio between the trial and control groups participants were assigned to the remaining group once one group reached capacity Participants who chose an odd number were assigned to the SpineCare based SRT group trial group TG and those who chose an even number were assigned to the SRT group without SpineCare control group CG
24 Outcomes 241 Primary Outcome Measure The primary outcome was the Numerical Rating Scale NRS score which was used to quantify the subjective pain experienced by the patient over the past week Patients selected a number that best reflected their pain intensity where 0 indicates no pain and 10 represents extreme pain with higher values indicating greater severity of pain There is consensus that the NRS has greater validity and intensity compared to other instruments The Pearson correlation coefficient r 093 indicating the correlation be-tween the NRS and Visual Analog Scale indicates robust validity and reliability
242 Secondary Outcome Measures The secondary outcome measure was Cobbs angle which is typically used to assess the severity of scoliosis Cobbs angle is defined as the angle between a line parallel to the upper border of the upper vertebra and a line parallel to the lower border of the lowermost vertebra of the lateral curvature of the spine The inter-rater and intrarater reliability coefficients for measuring Cobbs angle are 0970 and 0969 respectively
243 Safety Adverse events were monitored through patient interviews before and after treatment Participants were also instructed to notify the medical team by phone any time upon occurrence of an adverse event
25 Interventions Korean medicine doctors performed the treatment regimens for both groups The TG underwent SRT with SpineCare while the CG underwent SRT without SpineCare Treat-ment was administered for six consecutive weeks with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks No additional treatments eg procedures or surgeries were allowed during the six-week period To analyze pain according to the number of treatment sessions a counselor assessed patients using the NRS after each of the ten treatment sessions To compare the differences in Cobbs angle between the groups X-rays were performed after the first and tenth treatment sessions Detailed records of adverse events were maintained before and after each treat-ment session
251 Spinal Realignment Therapy SRT an original spinal alignment technique developed by the Society of Spinal Conduction Exercise and Manipulation functions as a diagnostic and manual therapeutic technique to promote balance and improve harmony in the human body In this study SRT was implemented in three steps
Step 1 entailed the application of traction With the patient lying on their side the practitioner grasps the leg on top at the dorsum and heel and slowly pulls it This motion slightly dislocates the femoral head from the hip joint allowing it to realign to its normal position thereby relieving deformities in the hip joint and tension in the surrounding muscles and soft tissues Next the patient lies prone with knees bent The ankles are then secured with SpineCares ankle braces and the knees are lifted slightly against gravity In this position the practitioner uses their hands or feet to apply frictional force pushing the sacrum towards the direction of the coccyx to correct the formers position
Step 2 entails the application of pressure and thrust This step treats pelvic imbalance while the patient is prone with the lower limbs lifted against gravity The practitioner places their hands or feet on the patients right and left iliac crests sacroiliac joints and sacrum using their body weight to exert pressure This process aims to correct any misa-lignment of the sacrum and sacroiliac joints as well as the imbalance of the left and right ilia
Step 3 entails securing the intervertebral space The practitioner addresses the im-balance in the thoracolumbar region while the patient remains prone with the lower limbs lifted against gravity The practitioner applies pressure sequentially to the patients deformed sacral spinous processes lumbar spinous processes and thoracic spinous pro-cesses using their hands or feet This technique aims to align the position of the sacrum the space between L5-S1 and the space between the facet joints and spinous processes of the lumbar and thoracic segments to their normal positions
252 SpineCare In the TG patients lay prone on the SpineCare mattress When patients bend their knees the practitioner secures both ankles in SpineCares ankle braces Next the legs are lifted against gravity to a height of 1-5 cm above the floor till a point that does not strain the patients pelvis based on the physicians judgment In this position steps 1-3 of the SRT are performed After treatment the legs are lowered to the floor using SpineCares ankle braces
The CG underwent steps 1-3 while lying prone on a regular therapy mattress
26 Statistical Analysis Statistical analyses were performed using SPSS 180 for Windows SPSS Inc Chicago IL USA NRS scores after each treatment session were compared sessions 1-10 Data between the TG and CG were compared using Wilcoxons signed-rank test and the Mann-Whitney U test The values of Cobbs angle at baseline session 1 and after the tenth treatment session were compared All data were presented as the mean standard devia-tion or number p-values 05 were deemed statistically significant Odds ratios were computed for comparison between the TG and CG including the main analysis and re-sults were deemed significant when the 95 confidence interval CI did not include 1 Adverse events were presented as frequencies and percentages and the chi-squared test or Fishers exact test Fishers exact test is used when more than 25 of the cells have an ex-pected frequency of less than 5 was used to compare the groups as needed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None