Ignite Creation Date:
2024-10-25 @ 8:02 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06514599
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
CRP Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparison of The Efficacy of CRP Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPD
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AECOPD
Brief Summary:
Acute Exacerbations of Chronic Obstructive Pulmonary Disease AECOPD are one of the chief causes for admission to Emergency Department AECOPD is a significant cause for mortality and morbidity worldwide Emergency Medicine Physicians frequently manage these patients Predicting the severity and possible prognosis of AECOPD is an important task for Emergency Medicine Physicians as treatment options and aggressiveness may depend on these predictions In our study we aimed to compare different biomarkers such as Procalcitonin Pro-Brain Natriuretic Peptide Pro-BNP and C-Reactive Protein CRP on their efficacy at predicting the severity and prognosis of AECOPD
We analyzed the data of the selected 196 patients with the diagnosis AECOPD according to the Global Initiative for Chronic Obstructive Lung Disease GOLD 2024 guide who were admitted to our Emergency Department between 15022023 and 15022024
We analyzed the data of the selected 196 patients with the diagnosis AECOPD according to the Global Initiative for Chronic Obstructive Lung Disease GOLD 2024 guide who were admitted to our Emergency Department between 15022023 and 15022024
Detailed Description:
Chronic Obstructive Pulmonary Disease COPD is an important health concern worldwide and causes serious mortality and morbidities Although prevalences can differ across different countries it was predicted that 480 million people are affected from COPD in 2020 alone 1
COPD is a condition that is characterized by an irreversible chronic inflammation which occurs within the airways the pulmonary vasculature and parenchyma of the lungs As a part of the progress of this disease cough dyspnea and sputum production could become almost permanent as symptoms Furthermore depending on seasonal changes COPD can present itself with exacerbations lowering the life quality of the patient and potentially overloading the healthcare systems across the world
COPD exacerbations influence the general condition of the patient They can cause admittance rates of COPD patient to significantly increase They can also cause mortalities as well A COPD patient can have a 5-year mortality rate of up to 50 if they are hospitalized with a COPD exacerbation 2 COPD exacerbations are diagnosed with a detailed medical history physical examination and necessary diagnostic tests According the GOLD 2024 guidelines in order to diagnose and classify a patient with a preliminary diagnosis of a COPD exacerbation Visual Analogue Scale VAS dyspnea score respiratory rate heart rate resting oxygen saturation arterial blood gas and C-reactive protein CRP levels are among these necessary diagnostic tests
There are studies mentioning CRP and Procalcitonin levels as independent diagnostic biomarkers for asthma and COPD exacerbations 3 There are also studies with findings that support the idea of using CRP and Procalcitonin levels as independent biomarkers to guide the antibiotic therapy in these patients 3-6 In addition to these markers Pro Brain Natriuretic Peptide Pro-BNP is found to be a potentially effective biomarker in predicting the prognosis of COPD patients both independently and alongside other cardiac biomarkers in a number of studies 7
In this study we have aimed to compare the efficacy of CRP Procalcitonin and Pro-BNP as diagnostic and prognostic markers in COPD patients We focused specifically on Procalcitonin and Pro-BNP and if there is any potential superiority of these biomarkers against CRP while evaluating COPD exacerbation patients
This prospective and observational study was conducted in an emergency department ED of a tertiary care referral center for the western part of Istanbul Approximately 80-100 patients with various types of life-threatening emergencies daily receive healthcare service in the red area of the ED Respiratory distress dyspnea and acute lung diseases are leading causes of emergency admission in our department Our ED involved fully equipped and well-qualified critical care unit and resuscitation areas to provide urgent care and life-saving interventions for those patients Thus this study was conducted under optimal infrastructural conditions for patients with COPD exacerbation
The patients for this study were recruited in the ED between 15022023-15022024 In order to form a database to use for our research a data collection form was organized for each individual This form compromised of the patients saturation without supplemental oxygen heart rate in beats per minute blood pressure with both systolic and diastolic values separately recorded body temperature Electrocardiogram and respiratory rate with all of them being measured at admittance A detailed medical history including the previous and chronic diseases prescription medicines past surgeries or invasive procedures and smoking habits were also added to this data collection form
COPD is a condition that is characterized by an irreversible chronic inflammation which occurs within the airways the pulmonary vasculature and parenchyma of the lungs As a part of the progress of this disease cough dyspnea and sputum production could become almost permanent as symptoms Furthermore depending on seasonal changes COPD can present itself with exacerbations lowering the life quality of the patient and potentially overloading the healthcare systems across the world
COPD exacerbations influence the general condition of the patient They can cause admittance rates of COPD patient to significantly increase They can also cause mortalities as well A COPD patient can have a 5-year mortality rate of up to 50 if they are hospitalized with a COPD exacerbation 2 COPD exacerbations are diagnosed with a detailed medical history physical examination and necessary diagnostic tests According the GOLD 2024 guidelines in order to diagnose and classify a patient with a preliminary diagnosis of a COPD exacerbation Visual Analogue Scale VAS dyspnea score respiratory rate heart rate resting oxygen saturation arterial blood gas and C-reactive protein CRP levels are among these necessary diagnostic tests
There are studies mentioning CRP and Procalcitonin levels as independent diagnostic biomarkers for asthma and COPD exacerbations 3 There are also studies with findings that support the idea of using CRP and Procalcitonin levels as independent biomarkers to guide the antibiotic therapy in these patients 3-6 In addition to these markers Pro Brain Natriuretic Peptide Pro-BNP is found to be a potentially effective biomarker in predicting the prognosis of COPD patients both independently and alongside other cardiac biomarkers in a number of studies 7
In this study we have aimed to compare the efficacy of CRP Procalcitonin and Pro-BNP as diagnostic and prognostic markers in COPD patients We focused specifically on Procalcitonin and Pro-BNP and if there is any potential superiority of these biomarkers against CRP while evaluating COPD exacerbation patients
This prospective and observational study was conducted in an emergency department ED of a tertiary care referral center for the western part of Istanbul Approximately 80-100 patients with various types of life-threatening emergencies daily receive healthcare service in the red area of the ED Respiratory distress dyspnea and acute lung diseases are leading causes of emergency admission in our department Our ED involved fully equipped and well-qualified critical care unit and resuscitation areas to provide urgent care and life-saving interventions for those patients Thus this study was conducted under optimal infrastructural conditions for patients with COPD exacerbation
The patients for this study were recruited in the ED between 15022023-15022024 In order to form a database to use for our research a data collection form was organized for each individual This form compromised of the patients saturation without supplemental oxygen heart rate in beats per minute blood pressure with both systolic and diastolic values separately recorded body temperature Electrocardiogram and respiratory rate with all of them being measured at admittance A detailed medical history including the previous and chronic diseases prescription medicines past surgeries or invasive procedures and smoking habits were also added to this data collection form
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None