Ignite Creation Date:
2024-10-25 @ 7:59 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06619444
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-26
Brief Title:
Dose-Response to Resistance Exercise on Cardiovascular Health
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Dose-Response to Resistance Exercise on Cardiovascular Health
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DoReps
Brief Summary:
A large body of evidence indicates numerous health benefits of physical activity including prevention of cardiovascular disease CVD the leading cause of death in the US This evidence has led to US Physical Activity Guidelines that recommend 150 minweek of moderate or 75 minweek of vigorous aerobic exercise AE plus resistance exercise RE such as weight lifting on 2 daysweek To date current research has mostly focused on AE and we know a great deal about the dose-response relation between AE and health resulting in clear and practical guidance to the public on the recommended dose in minweek However currently far less is known about the dose-response for RE 2 daysweek are recommended but with no duration specified Thus this project aims to provide clarity on the dose relationship between RE and health This project will significantly contribute to developing more effective CVD prevention approaches advancing prescriptive intervention guidelines by helping to fill the important gaps in knowledge on effective minimum dose beneficial optimal dose and safe maximum dose of RE for CVD prevention Thus advancing prescriptive intervention guidelines and provide important insights for future science of physical activity and health
Detailed Description:
Participants will be randomly assigned to 1 of four research conditions at varying dosage of resistance exercise RE for the duration of 1 year either 0 min 30 min 60 min or 120 min of weekly RE in addition to 60 min of weekly aerobic exercise AE Total exercise duration will be split between 2 weekly sessions Participants in all four groups will receive healthy lifestyle education sessions and will track daily steps food intake and activity levels throughout the 1-year intervention Participants will also complete baseline 6-month and 12-month physical examinations which will include assessments of blood pressure blood lipids body composition and aerobic and muscular fitness During the first 6 months of intervention will occur in a supervised lab-based setting Changes in Cardiovascular disease CVD risk factors as well as potential mechanisms arterial stiffness and inflammatory markers that might explain a J-shaped dose-response from baseline to 6 months will be assessed in each of the 4 groups The second 6 months will follow the same exercise intervention as the first 6 months However all participants will be provided with a free health club membership The second 6 months will be used to investigate the RE dose associated with best adherence in a free-living environment during the second 6 months In addition all measures taken at 6 months will also be assessed again at 12 months to examine the long-term effects of different doses of RE as secondary outcomes given that compliance will not be tightly enforced by staff in this unsupervised free-living condition In this case the investigators will further carefully consider exercise adherence in data analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None