Ignite Creation Date:
2024-10-25 @ 7:56 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06653231
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-20
Brief Title:
Assessment the Efficacy of Curcumin Local Delivery Gel in Treatment of Periodontitis in Smokers RCT
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment the Efficacy of Curcumin Local Delivery Gel in Treatment of Periodontitis in Smokers Randomized Controlled Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Smokers usually respond less favourably to non-surgical periodontal treatment compared to non-smokers Numerous studies reported that smoker patients exhibited less reduction in probing depth and less gains in clinical attachment level values following scaling and root planing Kanmaz et al 2021 Alwithanani 2023
Several studies have proposed the use of adjunctive treatment approaches such as localsystemic antimicrobials and anti-inflammatory agents to improve the effects of basic periodontal therapy in smokers However no studies have been published evaluated the conventional management of topically delivered curcumin gel in conjunction with scaling and root planing demonstrating its ability to improve periodontal outcomes in smokers
Meanwhile some clinical trials indicate that local and systemic administration of curcumin can enhance the results of SRP in periodontal treatment Local delivery allows higher concentrations of the active compounds in the diseased site and avoids possible adverse effects of systemic administration
Several studies have proposed the use of adjunctive treatment approaches such as localsystemic antimicrobials and anti-inflammatory agents to improve the effects of basic periodontal therapy in smokers However no studies have been published evaluated the conventional management of topically delivered curcumin gel in conjunction with scaling and root planing demonstrating its ability to improve periodontal outcomes in smokers
Meanwhile some clinical trials indicate that local and systemic administration of curcumin can enhance the results of SRP in periodontal treatment Local delivery allows higher concentrations of the active compounds in the diseased site and avoids possible adverse effects of systemic administration
Detailed Description:
Tobacco use increases the risk and progression of periodontitis by multiple factors including decreased gingival perfusion which restricts nutrients and oxygen delivery as well as the removal of waste products In addition it affects the circulating levels of immune-inflammatory cells in gingival crevicular fluid and affects the dysbiosis microbiota reducing the ability of the periodontium to repair
Curcumin is an extract from the turmeric plant Curcuma longa L It has been shown potent anti-microbial anti-carcinogenic antiviral antioxidant and anti-inflammatory properties
In periodontitis curcumin plays a pivotal role in anti-inflammatory properties by inhibiting pro-inflammatory cytokines reducing the prostaglandin biosynthesis inhibiting the mRNA and protein expression of cyclo-oxygenase-2 through down-regulation of NF-kB activation
Meanwhile some clinical trials indicate that local and systemic administration of curcumin can enhance the results of SRP in periodontal treatment local delivery allows higher concentrations of the active compounds in the diseased site and avoids possible adverse effects of systemic administration Pérez-Pacheco et al 2021 Borgohain et al 2023 Chatzopoulos et al 2023
Curcumin is an extract from the turmeric plant Curcuma longa L It has been shown potent anti-microbial anti-carcinogenic antiviral antioxidant and anti-inflammatory properties
In periodontitis curcumin plays a pivotal role in anti-inflammatory properties by inhibiting pro-inflammatory cytokines reducing the prostaglandin biosynthesis inhibiting the mRNA and protein expression of cyclo-oxygenase-2 through down-regulation of NF-kB activation
Meanwhile some clinical trials indicate that local and systemic administration of curcumin can enhance the results of SRP in periodontal treatment local delivery allows higher concentrations of the active compounds in the diseased site and avoids possible adverse effects of systemic administration Pérez-Pacheco et al 2021 Borgohain et al 2023 Chatzopoulos et al 2023
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None