Ignite Creation Date:
2024-10-25 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06515795
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-10
Brief Title:
Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Evaluation of the Safety and Efficacy of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hypertension remains the main preventable cause of cardiovascular disease CVD and all-cause mortality both in Europe and globally Resistant hypertension a severe phenotype of hypertension is defined as a blood pressure BP that remains above the management goal despite using three different antihypertensive agents of different classes at the maximum or maximum tolerated dose or controlled BP on four or more antihypertensive medications Hypertension remains a poorly controlled risk factor on a global scale and the prevalence of resistant hypertension is also growing - it is now estimated to be around 10-20
At the moment there is robust evidence establishing the antihypertensive effects of exercise The acute reduction of BP after a single bout of exercise is known as post-exercise hypotension
In recent years the number of investigations into the benefits of isometric exercise in the treatment of hypertension has increased due to its ease of access and potential for use In a recently published meta-analysis the authors pointed to isometric exercise as the most effective type of exercise in reducing systolic and diastolic BP
Given the scarceness of data regarding the safety and efficacy of isometric exercise in individuals with resistant hypertension and since the acute response to exercise may help to identify people who respond to exercise as antihypertensive therapy the objective of this study is to analyse the acute effect on BP levels of two different isometric exercises - isometric handgrip IHG and isometric wall squat IWS regarding safety and efficacy in people with resistant hypertension
The aim is to analyse if isometric exercises are safe in this population through the assessment of BP during the execution of the exercises Besides that the comparison of IHG and IWS with the control session and between one and another will help to understand which form of isometric exercise is most effective and has the longest lasting impact on reducing BP
Each participant must complete an acclimatization session in which the procedures will be explained data will be collected and the intensity of IHG and IWS will be assessed Subsequently each participant must complete three randomly assigned experimental sessions a non-exercise control session and two exercise sessions in which they will follow the protocols currently used in the literature IHG at 30 of Maximum Voluntary Contraction and IWS at 95 of peak Heart Rate
At the moment there is robust evidence establishing the antihypertensive effects of exercise The acute reduction of BP after a single bout of exercise is known as post-exercise hypotension
In recent years the number of investigations into the benefits of isometric exercise in the treatment of hypertension has increased due to its ease of access and potential for use In a recently published meta-analysis the authors pointed to isometric exercise as the most effective type of exercise in reducing systolic and diastolic BP
Given the scarceness of data regarding the safety and efficacy of isometric exercise in individuals with resistant hypertension and since the acute response to exercise may help to identify people who respond to exercise as antihypertensive therapy the objective of this study is to analyse the acute effect on BP levels of two different isometric exercises - isometric handgrip IHG and isometric wall squat IWS regarding safety and efficacy in people with resistant hypertension
The aim is to analyse if isometric exercises are safe in this population through the assessment of BP during the execution of the exercises Besides that the comparison of IHG and IWS with the control session and between one and another will help to understand which form of isometric exercise is most effective and has the longest lasting impact on reducing BP
Each participant must complete an acclimatization session in which the procedures will be explained data will be collected and the intensity of IHG and IWS will be assessed Subsequently each participant must complete three randomly assigned experimental sessions a non-exercise control session and two exercise sessions in which they will follow the protocols currently used in the literature IHG at 30 of Maximum Voluntary Contraction and IWS at 95 of peak Heart Rate
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None