Ignite Creation Date:
2024-10-25 @ 7:54 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06538454
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-29
Brief Title:
Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Acute and Chronic Effects of Resistance Training Intensity on Cardiovascular Parameters of Postmenopausal Women With Systemic Arterial Hypertension
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this clinical trial is to understand about the effects of resistance training RT intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension SAH The main research questions are
Does the intensity of RT impact blood pressure BP in postmenopausal women with SAH
How does RT intensity affect heart rate HR and their variability HRV endothelial function EF and nitric oxide NO biomarker synthesis in this population
What are the effects of RT intensity on affectivity and rate of perceived exertion RPE
Researchers will compare two different intensities of RT 60 of the load for 1 repetition maximum 1RM and 80 of 1RM to determine their effects on the mentioned cardiovascular and perceptual parameters
Participants will
In the acute experiment
Perform the same RT session in a crossover design training with 60 of 1RM in one condition and 80 of 1RM in another condition
Have BP HR and HRV measured before immediately after and for one hour post-session
Report affectivity before each session and at the end along with RPE
In the chronic experiment
Be randomized into two groups one training with 60 of 1RM and the other with 80 of 1RM
Undergo a 10-week intervention period with evaluations before during and after the intervention
Have BP HR affective responses and RPE measured at multiple time points
Have EF HRV and salivary concentrations of NO biomarkers assessed before and after the intervention
Does the intensity of RT impact blood pressure BP in postmenopausal women with SAH
How does RT intensity affect heart rate HR and their variability HRV endothelial function EF and nitric oxide NO biomarker synthesis in this population
What are the effects of RT intensity on affectivity and rate of perceived exertion RPE
Researchers will compare two different intensities of RT 60 of the load for 1 repetition maximum 1RM and 80 of 1RM to determine their effects on the mentioned cardiovascular and perceptual parameters
Participants will
In the acute experiment
Perform the same RT session in a crossover design training with 60 of 1RM in one condition and 80 of 1RM in another condition
Have BP HR and HRV measured before immediately after and for one hour post-session
Report affectivity before each session and at the end along with RPE
In the chronic experiment
Be randomized into two groups one training with 60 of 1RM and the other with 80 of 1RM
Undergo a 10-week intervention period with evaluations before during and after the intervention
Have BP HR affective responses and RPE measured at multiple time points
Have EF HRV and salivary concentrations of NO biomarkers assessed before and after the intervention
Detailed Description:
Physical training has been recommended as a non-pharmacological therapeutic strategy that can promote improvements in blood pressure levels in patients with systemic arterial hypertension SAH Resistance training RT has emerged due to the various benefits it promotes including reducing blood pressure BP in this population as improvements in heart rate variability HRV and endothelial function EF Guidelines suggest an intensity between 50 and 80 of 1 repetition maximum 1RM in RT reflecting a range of maximum repetitions between 9 and 26 However there is a lack of studies that have made a direct comparison of the effect of different intensities in cardiovascular parameters of these patients Therefore the objective of this study will be to evaluate acutely and chronically the effect of RT intensity on BP heart rate HR HRV endothelial function salivary concentrations of nitric oxide NO biomarker synthesis also affectivity and rate of perceived exertion RPE of postmenopausal women with SAH The study will be conducted in two stages with two experiments one acute and one chronic In the acute experiment with a crossover design participants will perform the same RT session with the order of these sessions being random but in one condition they will train with 60 of 1RM and in another with 80 of 1RM BP HR and HRV will be measured before at the end and for one hour after the session hypotensive effect of the exercise Affectivity will be measured before each test and at the end together with PSE In the chronic study participants will be randomized to one group that will train with 60 of 1RM and another group that will train with 80 of 1RM Before during and after the intervention which will last 10 weeks participants will be evaluated for BP HR affective responses and RPE with EF HRV and salivary concentrations of NO biomarkers measured before and after the intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None