Ignite Creation Date:
2024-10-25 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06637189
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-04-25
Brief Title:
Protocol with Progestin-primed Ovarian Stimulation PPOS from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Protocol with Progestin-primed Ovarian Stimulation PPOS from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PPDUO
Brief Summary:
The PPOS protocol Progestin-primed Ovarian Stimulation involves avoiding ovulation during ovarian stimulation with progesterone It is a reliable and safe protocol that has been widely used in recent years for in vitro fertilization as it reduces the number of injections needed during controlled ovarian stimulation and is more cost-effective for patients
The aim of this study is to compare two methods of ovarian stimulation for in vitro fertilization the PPOS protocol Group A and the conventional protocol with injected antagonists Group B The goal is to determine whether both methods are equally effective in obtaining euploid embryos in the context of double ovarian stimulation
The aim of this study is to compare two methods of ovarian stimulation for in vitro fertilization the PPOS protocol Group A and the conventional protocol with injected antagonists Group B The goal is to determine whether both methods are equally effective in obtaining euploid embryos in the context of double ovarian stimulation
Detailed Description:
Hypothesis
Hypothesis The number of euploid embryos obtained in a DUOSTIM cycle with PPOS is not inferior to that obtained with the use of antagonists
General and Specific Objectives
Main Objective To study if there is a difference in the number of euploid embryos obtained in two groups of patients undergoing embryo accumulation for PGT-A through double ovarian stimulation comparing two methods of pituitary suppression Progesterone use from the start of stimulation and the use of GnRH antagonists
Secondary Objectives
Evaluate if there are differences between both groups regarding the number of MII oocytes
Evaluate if there are differences between both groups regarding the number of cumulus-oocyte complexes COC
Study the differences between both groups regarding the total consumption of gonadotropins
Evaluate if there are differences between both groups regarding the number of stimulation days
Evaluate if there are differences in fertilization rate after microinjection Evaluate if there are differences between both groups regarding the cancellation rate
Evaluate if there are differences between both groups regarding the number of total embryos
Evaluate if there are differences between both groups regarding the number of embryos subjected to trophectoderm biopsy
Hypothesis The number of euploid embryos obtained in a DUOSTIM cycle with PPOS is not inferior to that obtained with the use of antagonists
General and Specific Objectives
Main Objective To study if there is a difference in the number of euploid embryos obtained in two groups of patients undergoing embryo accumulation for PGT-A through double ovarian stimulation comparing two methods of pituitary suppression Progesterone use from the start of stimulation and the use of GnRH antagonists
Secondary Objectives
Evaluate if there are differences between both groups regarding the number of MII oocytes
Evaluate if there are differences between both groups regarding the number of cumulus-oocyte complexes COC
Study the differences between both groups regarding the total consumption of gonadotropins
Evaluate if there are differences between both groups regarding the number of stimulation days
Evaluate if there are differences in fertilization rate after microinjection Evaluate if there are differences between both groups regarding the cancellation rate
Evaluate if there are differences between both groups regarding the number of total embryos
Evaluate if there are differences between both groups regarding the number of embryos subjected to trophectoderm biopsy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None