Ignite Creation Date:
2024-10-25 @ 7:52 PM
Last Modification Date:
2024-10-26 @ 3:37 PM
Study NCT ID:
NCT06540976
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-04-16
Brief Title:
Posterior Cingulate Cortex and Executive Control of Episodic Memory
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Posterior Cingulate Cortex and Executive Control of Episodic Memory
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project will use intracranial recordings and stimulation of the human brain to understand the unique contributions of the posterior cingulate cortex PCC to episodic memory behavior The goal is to test how distinct subregions of the PCC differentially contribute to memory-based decisions eg have I seen this picture before The ability to perform invasive studies of the human brain is through routine clinical monitoring of brain activity which occurs during the neurosurgical treatment of epilepsy However this project only focuses on the basic science of PCC and memory behavior Specifically the investigators will use single-0cell and population measures of brain activity to test a new theory of PCC function which focuses on the executive processes needed to support memory retrieval and memory-based decisions By studying the PCC a convergence zone of memory and executive brain systems progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease eg Alzheimers disease and multiple psychiatric conditions eg schizophrenia implicating PCC dysfunction
Detailed Description:
This project reflects a basic experimental study involving human participants BESH which focuses on the neuroscience of episodic memory Episodic memory involves the encoding and retrieval of past experiences to support learned behavior Aside from these mnemonic processes it also requires the ability to regulate memory ie executive processes For example many real-world decisions will engage episodic retrieval for which executive processes must help to integrate and evaluate the quality of remembered information mnemonic evidence and guide behavior to either decision action or continued memory search While the neural basis of episodic memory encoding and retrieval have been a major focus of research far less is known about its executive aspects Executive mnemonic functions likely involve an anatomical substrate that is i multisensoryassociative ii engaged by memoryexecutive processing and iii strongly interconnected with both mnemonic regions in the medial temporal lobe MTL and executive prefrontal PFC regions Prior non-human primate studies as well as human electrophysiology and neuroimaging data suggest that posterior cingulate cortex PCC fulfills these criteria The central hypothesis of this work is that the PCC plays a critical and unique role in executive control of episodic memory retrieval The investigators further hypothesize that it comprises three subregions regions dorsal PCC ventral PCC and retrosplenial cortex RSC These subregions are proposed to play complementary roles corresponding to retrieval regulation retrieval integration and scene perception and transformation respectively In this account PCC is a convergence zone of memory and executive systems whose specific functional organization accounts for prior discrepancies between studies and species The investigators will utilize human intracranial recordings including single-cell data and stimulation within PCC to better resolve the functional organization of this region The investigators will employ an array of cognitive experiments to delineate three PCC subregions supporting the encoding retrieval and executive control of memory processing Aim 1 In delineating these subregions the investigators will also seek to differentiate PCC responses from those occurring in memory and executive functional networks Aim 2 Finally based on these observations the investigators will demonstrate the causal role of PCC subregions on behavior and localnetwork activity Aim 3 By studying PCC a convergence zone of memory and executive systems progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease eg Alzheimers disease and multiple psychiatric conditions eg schizophrenia implicating PCC dysfunction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None