Ignite Creation Date:
2024-10-25 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 3:40 PM
Study NCT ID:
NCT06591897
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-08
Brief Title:
Exploration of Gender Differences in Liver Aging
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Exploration of Gender Differences in Liver Aging
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The liver is an important metabolic organ in the body It participates in central metabolic activities to maintain systemic homeostasis It is also one of the most vulnerable organs in the process of individual aging During aging the volume blood flow metabolic capacity and regenerative capacity of the liver decrease Liver function changes with age can lead to age-related systemic susceptibility diseases
Therefore understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly populationOn the other hand gender factors also affect organ function leading to differences in human aging and disease outcomesAt present the omics research on liver aging is mainly based on tissue-level transcription protein or metabolomics and most of the conclusions are focused on hepatocytes However for other cell types and microenvironment interactions people know little about the aging changes at the cellular levelBased on the current research status this study aims to explore the gender differences in the process of liver aging using emerging technologies such as the combination of single-cell multi-omics and spatial localization to reveal the factors driving liver aging from a gender perspective and to promote the development of accurate interventions for aging and aging-related diseases
Therefore understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly populationOn the other hand gender factors also affect organ function leading to differences in human aging and disease outcomesAt present the omics research on liver aging is mainly based on tissue-level transcription protein or metabolomics and most of the conclusions are focused on hepatocytes However for other cell types and microenvironment interactions people know little about the aging changes at the cellular levelBased on the current research status this study aims to explore the gender differences in the process of liver aging using emerging technologies such as the combination of single-cell multi-omics and spatial localization to reveal the factors driving liver aging from a gender perspective and to promote the development of accurate interventions for aging and aging-related diseases
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None