Ignite Creation Date:
2024-10-25 @ 7:50 PM
Last Modification Date:
2024-10-26 @ 3:39 PM
Study NCT ID:
NCT06589232
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-04-10
Brief Title:
Threshold Dose Distribution for Pistachio Allergy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Threshold Dose Distribution for Pistachio Allergy in Children
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main objective of this study is to describe the distribution of reactogenic thresholds for pistachio The secondary objectives are to 1 describe the clinical severity of allergic reactions to pistachio in an oral challenge test 2 compare the reactogenic thresholds of pistachio and cashew nut on matched data and 3 evaluate predictive factors of a low reactogenic threshold
Detailed Description:
Nuts including almonds walnuts cashews pistachio and hazelnut are among the food allergens most frequently involved in food allergies in children with an estimated prevalence between 005 and 49
According to data from the Allergo-Vigilance Network peanuts and the group of nuts led by cashews are alone responsible for 514 of food anaphylaxis in children
The pistachio belongs to the same botanical family as the cashew nut Anacardiumouest and the mango Mangifera indica the anacardiaceae Botanically pistachio and cashew are closely related and can both be responsible for moderate to severe immediate allergic reactions Furthermore in a previous publication by the team co-sensitization to pistachio was observed in 98 of children allergic to cashew nuts with only 34 confirmed allergic to pistachio
In the case of allergy to both anacardiaceae in a small number of patients the investigators reported a reactogenic threshold for pistachio greater than or equal to that for cashew nuts
To our knowledge there is currently only one study that has evaluated the reactogenic threshold for pistachio compared to other nuts
According to data from the Allergo-Vigilance Network peanuts and the group of nuts led by cashews are alone responsible for 514 of food anaphylaxis in children
The pistachio belongs to the same botanical family as the cashew nut Anacardiumouest and the mango Mangifera indica the anacardiaceae Botanically pistachio and cashew are closely related and can both be responsible for moderate to severe immediate allergic reactions Furthermore in a previous publication by the team co-sensitization to pistachio was observed in 98 of children allergic to cashew nuts with only 34 confirmed allergic to pistachio
In the case of allergy to both anacardiaceae in a small number of patients the investigators reported a reactogenic threshold for pistachio greater than or equal to that for cashew nuts
To our knowledge there is currently only one study that has evaluated the reactogenic threshold for pistachio compared to other nuts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None