Ignite Creation Date:
2024-10-25 @ 7:48 PM
Last Modification Date:
2024-10-26 @ 3:35 PM
Study NCT ID:
NCT06515886
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-07-15
Brief Title:
Characterizing the Inflammation Around Dental Implants Bacterial Infection Hypersensitivity or Both
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Characterizing the Inflammation Around Dental Implants Bacterial Infection Hypersensitivity or Both
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The use of titanium dental implants has become a common modern treatment to restore teeth Although the success rate of dental implants is high inflammation around the dental implant still occurs The current study will investigate if the inflammation around the implant is due to bacterial infection hypersensitivity or both
Detailed Description:
The objective of the study is to
1 Establish the levels of cytokines in peri-implant crevicular fluid and test the levels of cytokines associated with hypersensitivity Type 2 Interleukin-4 IL-4 Interleukin-5 IL-5 and Interleukin-13 IL-13 and bacterial infection Type 1 and 3 Interleukin-1 alpha IL-1α Interleukin-2 IL-2 Interleukin-6 IL-6 Interleukin-8 IL-8 Interleukin-10 IL-10 Interleukin-12 IL-12 Interleukin-17 IL-17 Granulocyte-Macrophage Colony-Stimulating Factor GM-CSF Interferon-gamma IFN-γ Tumor Necrosis Factor-alpha TNF-α between healthy implants and inflamed implants mucositis and peri-implantitis
2 Compare the levels of Matrix Metalloproteinases MMPs MMP-1 MMP-2 and MMP-9 and Receptor Activator of Nuclear Factor Kappa-Β Ligand RANKL associated with tissue destruction and bone loss between healthy and inflamed implants
1 Establish the levels of cytokines in peri-implant crevicular fluid and test the levels of cytokines associated with hypersensitivity Type 2 Interleukin-4 IL-4 Interleukin-5 IL-5 and Interleukin-13 IL-13 and bacterial infection Type 1 and 3 Interleukin-1 alpha IL-1α Interleukin-2 IL-2 Interleukin-6 IL-6 Interleukin-8 IL-8 Interleukin-10 IL-10 Interleukin-12 IL-12 Interleukin-17 IL-17 Granulocyte-Macrophage Colony-Stimulating Factor GM-CSF Interferon-gamma IFN-γ Tumor Necrosis Factor-alpha TNF-α between healthy implants and inflamed implants mucositis and peri-implantitis
2 Compare the levels of Matrix Metalloproteinases MMPs MMP-1 MMP-2 and MMP-9 and Receptor Activator of Nuclear Factor Kappa-Β Ligand RANKL associated with tissue destruction and bone loss between healthy and inflamed implants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None