Ignite Creation Date:
2024-07-17 @ 12:07 PM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06467773
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-06-12
Brief Title:
TSPO-PETMRI in Surveillance of Neuroinflammation in the Central Nervous System
Sponsor:
Tongji Hospital
Organization:
Tongji Hospital
Study Overview
Official Title:
An Oberservational Study of Utility of TSPO-PETMRI Using the Radiotracer 18F-DPA-714 in Surveillance of Neuroinflammation in the Central Nervous System
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Central Nervous System CNS inflammation is an immune response activated in the brain and spinal cord by microglial cells and astrocytes commonly occurring under conditions such as central nervous system ischemia autoimmunity infection toxins and trauma
Microglial cells as the innate immune cells of the central nervous system are responsible for driving the inflammatory response and play a crucial role in sensing environmental changes responding to harmful stimuli and engulfing dead neurons They also present antigens to T lymphocytes mediating interactions between the peripheral immune system and the central nervous system Factors released by neuronal cells can either promote or inhibit inflammation and monitoring the level of inflammation driven by microglial cells is essential for the diagnosis and treatment of central nervous system diseases
MRI is the primary imaging method for central nervous system inflammation but it can be challenging to diagnose PETMR a technology that integrates PET and MR imaging provides high-quality diagnostic images and is valuable for the early detection diagnosis and assessment of central nervous system diseases The radioactive ligand 18F-DPA-714 PET targeting the translocation protein TSPO can visualize activated microglial cells which may have a gain effect in detecting active central nervous system inflammation
This study aims to explore the application of 18F-DPA-714 PETMR in the early diagnosis treatment evaluation and prognosis of central nervous system inflammation
Microglial cells as the innate immune cells of the central nervous system are responsible for driving the inflammatory response and play a crucial role in sensing environmental changes responding to harmful stimuli and engulfing dead neurons They also present antigens to T lymphocytes mediating interactions between the peripheral immune system and the central nervous system Factors released by neuronal cells can either promote or inhibit inflammation and monitoring the level of inflammation driven by microglial cells is essential for the diagnosis and treatment of central nervous system diseases
MRI is the primary imaging method for central nervous system inflammation but it can be challenging to diagnose PETMR a technology that integrates PET and MR imaging provides high-quality diagnostic images and is valuable for the early detection diagnosis and assessment of central nervous system diseases The radioactive ligand 18F-DPA-714 PET targeting the translocation protein TSPO can visualize activated microglial cells which may have a gain effect in detecting active central nervous system inflammation
This study aims to explore the application of 18F-DPA-714 PETMR in the early diagnosis treatment evaluation and prognosis of central nervous system inflammation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None