Ignite Creation Date:
2024-07-17 @ 12:07 PM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06467266
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-20
First Post:
2024-06-05
Brief Title:
Mechanistic Insights From Temporary Pacing in HFpEF
Sponsor:
Guys and St Thomas NHS Foundation Trust
Organization:
Guys and St Thomas NHS Foundation Trust
Study Overview
Official Title:
Mechanistic Insights From Multisite Pacing in Patients With Heart Failure With Preserved Ejection Fraction
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Heart failure with preserved ejection fraction HFpEF is characterised by impaired diastolic function A recent clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated pacing from indwelling permanent pacemakers including symptomatic improvement objective reductions in NT-proBNP level and AF-burden
The investigators aim to determine the underlying mechanisms behind these documented effects to investigate the acute intracardiac haemodynamic response to temporary multisite pacing in HFpEF participants and to gain further mechanistic insight with additional haemodynamic electrical and echocardiographic data collection during temporary pacing in this cohort This will all provide valuable information towards new potential targets of therapy
The investigators aim to determine the underlying mechanisms behind these documented effects to investigate the acute intracardiac haemodynamic response to temporary multisite pacing in HFpEF participants and to gain further mechanistic insight with additional haemodynamic electrical and echocardiographic data collection during temporary pacing in this cohort This will all provide valuable information towards new potential targets of therapy
Detailed Description:
In this research study the investigators will perform a one-off temporary pacing procedure in the catheter lab at St Thomas Hospital in patients with heart failure with preserved ejection fraction HFpEF During the short procedure the investigators will pace the heart at different heart rates and from different parts of the heart The investigators will measure the change in pressure inside the heart in response to each pacing sitemode and rate Altogether the investigators aim to find out how different pacing modes and heart rates impact how well the heart fills and pumps in HFpEF
The study will provide valuable information about the underlying mechanisms of pacing in HFpEF which could significantly influence the future direction of HFpEF management Specifically it will help the investigators to understand what types of pacemaker and pacing site or pacing mode may be chosen in HFpEF patients requiring pacing which accounts for around 20 of all HFpEF patients
The study will provide valuable information about the underlying mechanisms of pacing in HFpEF which could significantly influence the future direction of HFpEF management Specifically it will help the investigators to understand what types of pacemaker and pacing site or pacing mode may be chosen in HFpEF patients requiring pacing which accounts for around 20 of all HFpEF patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None