Ignite Creation Date:
2024-07-17 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06465277
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2023-09-06
Brief Title:
CMR Right Ventricular Contractile Reserve Following Lung Resection
Sponsor:
Belfast Health and Social Care Trust
Organization:
Belfast Health and Social Care Trust
Study Overview
Official Title:
Assessment of Right Ventricular Contractile Reserve Following Lung Resection by Dobutamine Stress Cardiac Magnetic Resonance a Feasibility Study
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Feasibility study investigating CMR dobutamine stress testing before and after lung resection
Detailed Description:
We hypothesise that following lung resection
1 the subtle decrease in RV function and increase in afterload we have demonstrated at rest is associated with a marked impairment of RV function on exercise termed impaired RV contractile reserve RVCreserve
2 impaired RVCreserve is associated with impaired functional capacity
In this study we aim to assess the feasibility of dobutamine stress cardiovascular magnetic resonance CMR scanning to assess RVCreserve pre- and post-operatively in patients undergoing lung resection
Additionally we hypothesise that one lung ventilation with and without lung resection is associated with biomarker evidence of RV injuryWe will perform peri-operative cardiac biomarkers to differentiate between the contribution of major surgery gastrectomy lung resection and oesophagectomy one lung ventilation lung resection and oesophagectomy and lung resection on RV injury
1 the subtle decrease in RV function and increase in afterload we have demonstrated at rest is associated with a marked impairment of RV function on exercise termed impaired RV contractile reserve RVCreserve
2 impaired RVCreserve is associated with impaired functional capacity
In this study we aim to assess the feasibility of dobutamine stress cardiovascular magnetic resonance CMR scanning to assess RVCreserve pre- and post-operatively in patients undergoing lung resection
Additionally we hypothesise that one lung ventilation with and without lung resection is associated with biomarker evidence of RV injuryWe will perform peri-operative cardiac biomarkers to differentiate between the contribution of major surgery gastrectomy lung resection and oesophagectomy one lung ventilation lung resection and oesophagectomy and lung resection on RV injury
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None