Ignite Creation Date:
2024-07-17 @ 11:59 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06480903
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-28
First Post:
2024-06-18
Brief Title:
Exploratory Study of EBV DNA Titre Clearance Whilst on Proton Beam Therapy
Sponsor:
The Christie NHS Foundation Trust
Organization:
The Christie NHS Foundation Trust
Study Overview
Official Title:
Exploratory Study of Plasma Epstein Barr Virus EBV DNA Clearance During Proton Beam Therapy PBT for Nasopharyngeal Carcinoma NPC
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ClearED
Brief Summary:
How does plasma Epstein-Barr Virus EBV DNA level change during definitive radiation therapy for nasopharyngeal carcinoma NPC in the teenage and young adult cohort and does it correlate with outcomes
Detailed Description:
Children with NPC achieve superior survival outcomes compared to adults 10 and the prognostic value of plasma Epstein-Barr Virus EBV DNA has not been studied in children Integration of MRI into early treatment response assessment will add further prognostic value and permits response-adapted therapy which can improve quality of survivorship children through toxicity reduction It also allows identification of patients who either have had or are likely to have a suboptimal response to treatment facilitating the potential consideration of treatment escalation
The sample size of this study is not intended to change clinical practice but rather provide a basis for international collaboration to achieve larger patient numbers
The sample size of this study is not intended to change clinical practice but rather provide a basis for international collaboration to achieve larger patient numbers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None