Ignite Creation Date:
2024-07-17 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06465017
Status:
RECRUITING
Last Update Posted:
2024-06-18
First Post:
2024-06-13
Brief Title:
ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 Trop-2 in Thyroid Cancer
Sponsor:
The First Affiliated Hospital of Xiamen University
Organization:
The First Affiliated Hospital of Xiamen University
Study Overview
Official Title:
ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 Trop-2 in Thyroid Cancer and Compared With 18F-FDG and 68Ga-FAPI
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of the study is to construct a noninvasive approach 68Ga-THP-Trop2 VHH PETCT to detect the Trop-2 expression of tumor lesions in patients with thyroid cancer and to identify patients benefiting from Trop-2 targeting antibody-drug conjugate treatment
Detailed Description:
As a new trophoblast cell-surface antigen 2 Trop-2 targeting PET radiotracer 68Ga-THP-Trop2 VHH is promising as an excellent imaging agent applicable to various cancers In this research subjects with thyroid cancer or highly suspected recurrence detection underwent contemporaneous 68Ga-THP-Trop2 VHH and standard-of-care imaging 18F-FDG and 68Ga-FAPI PETCT either for an initial assessment or for metastases or highly suspected recurrence detection Tumor uptake was quantified by the maximum standard uptake value SUVmax The numbers of positive tumor lesions of standard-of-care imaging and 68Ga-THP-Trop2 VHH PETCT were recorded by visual interpretation The diagnostic accuracy of 68Ga-THP-Trop2 VHH was calculated and compared to standard-of-care imaging
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None