Ignite Creation Date:
2024-07-17 @ 11:57 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06477211
Status:
RECRUITING
Last Update Posted:
2024-06-27
First Post:
2024-06-19
Brief Title:
DNA Methylation Biomarkers to Predict Survival After Surgery for Lung Adenocarcinoma
Sponsor:
Nanjing University
Organization:
Nanjing University
Study Overview
Official Title:
A Multicenter Retrospective Study Identifying DNA 5mC Predictors for LUAD Prognosis
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to assess DNA 5-methylcytosine 5mC methylation modifications in lung adenocarcinoma LUAD samples and develop a prognosis-predictive model for LUAD based on cancer tissue DNA 5mC levels The research will link post-surgical recurrence and survival outcomes to the DNA 5mC profiles of patients By collaborating with two hospitals in China this multicentral study will utilize over three years of prognostic data from LUAD patients to validate the models accuracy Additionally the research aims to explore the potential of the model in guiding adjuvant treatment strategies by comparing the differences in outcomes between high-risk patients who receive further treatment and those who do not This study aspires to enhance future treatment planning for LUAD patients providing personalized and effective therapeutic options based on precise prognostic predictions
Detailed Description:
Model Development
The methylation data will be analyzed to identify specific 5mC methylation patterns associated with post-surgical recurrence and survival outcomes
A prognostic model will be developed based on these methylation profiles to predict LUAD prognosis
Model Validation
Clinical data from LUAD patients at two hospitals in China including over three years of follow-up information will be used to validate the accuracy and reliability of the prognostic model
Statistical methods will be applied to assess the models predictive power and its ability to accurately stratify patients into different risk categories
Exploration of Follow-up and Adjuvant Therapy Guidance
The study will compare outcomes between high-risk patients who receive additional adjuvant treatment and those who do not based on the risk categories identified by the prognostic model
This comparison aims to explore the models potential in guiding adjuvant therapy decisions ultimately enhancing personalized treatment strategies and improving survival rates for LUAD patients
The methylation data will be analyzed to identify specific 5mC methylation patterns associated with post-surgical recurrence and survival outcomes
A prognostic model will be developed based on these methylation profiles to predict LUAD prognosis
Model Validation
Clinical data from LUAD patients at two hospitals in China including over three years of follow-up information will be used to validate the accuracy and reliability of the prognostic model
Statistical methods will be applied to assess the models predictive power and its ability to accurately stratify patients into different risk categories
Exploration of Follow-up and Adjuvant Therapy Guidance
The study will compare outcomes between high-risk patients who receive additional adjuvant treatment and those who do not based on the risk categories identified by the prognostic model
This comparison aims to explore the models potential in guiding adjuvant therapy decisions ultimately enhancing personalized treatment strategies and improving survival rates for LUAD patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None