Ignite Creation Date:
2024-07-17 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06497855
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-12
First Post:
2024-07-01
Brief Title:
Impact of Estimated Concentration of Propofol on Implicit Memory Formation
Sponsor:
University of Padova
Organization:
University of Padova
Study Overview
Official Title:
Impact of Target Controlled Infusion Estimated Concentration of Propofol on Implicit Memory Formation During Propofol-Remifentanil General Anaesthesia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen ie intravenous anaesthesia vs inhalatory one nor analgesic regimen ie low or high opioids usage has been identified for prevention
With this study the investigators aim to investigate if during Total Intravenous Anaesthesia with Target Controlled Infusion TIVA-TCI different concentrations of Propofol at loss of responsiveness maintenance and return of responsiveness can have a role in implicit memory formation
With this study the investigators aim to investigate if during Total Intravenous Anaesthesia with Target Controlled Infusion TIVA-TCI different concentrations of Propofol at loss of responsiveness maintenance and return of responsiveness can have a role in implicit memory formation
Detailed Description:
Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen ie intravenous anaesthesia vs inhalatory one nor analgesic regimen ie low or high opioids usage has been identified for prevention
With this study the investigators aim to investigate if during Total Intravenous Anaesthesia with Target Controlled Infusion TIVA-TCI different concentrations of Propofol at loss of responsiveness CeP RoR maintenance CePMA and return of responSiveness CeP RoR can have a role in implicit memory formation
20 most common italiaN words will be continuously presented to the anaesthetized patients from Loss of responsiveness to end of surgery
CeP RoR MA and LoR as well as patient state index PSi from Sedline monitor for hypnosis level monitoring will be recorded
Within 24 hours a trained psychologist will be present the patients the Word Steam Recognition Test Free Recall and Force Choice recognition task to asses the presence of implicit memory formation A second group who did not hear the words will be investigated to assess the role of chance in the above-mentioned test
With this study the investigators aim to investigate if during Total Intravenous Anaesthesia with Target Controlled Infusion TIVA-TCI different concentrations of Propofol at loss of responsiveness CeP RoR maintenance CePMA and return of responSiveness CeP RoR can have a role in implicit memory formation
20 most common italiaN words will be continuously presented to the anaesthetized patients from Loss of responsiveness to end of surgery
CeP RoR MA and LoR as well as patient state index PSi from Sedline monitor for hypnosis level monitoring will be recorded
Within 24 hours a trained psychologist will be present the patients the Word Steam Recognition Test Free Recall and Force Choice recognition task to asses the presence of implicit memory formation A second group who did not hear the words will be investigated to assess the role of chance in the above-mentioned test
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None