Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001923
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Transcranial Magnetic Stimulation for the Treatment of Phantom Pain
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Phantom Pain A Therapeutic Trial Using Transcranial Magnetic Stimulation
Status:
COMPLETED
Status Verified Date:
2002-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Phantom pain refers to the sensation of pain felt by patients who have had a limb amputated The treatment of phantom pain is often disappointing and is unable to provide adequate relief to the patients The area of the brain involved posterior parietal cortex PPC is found on the opposite side of the amputated limb For example if a patient has the right arm amputated the left posterior parietal cortex is involved in the phantom pain
Researchers believe that if they can decrease activity in the posterior parietal cortex they may be able to reduce phantom pain
Researchers plan to use low frequency 1 Hz transcranial magnetic stimulation TMS to decrease the excitability of the PPC opposite the side of the amputated limb TMS involves the placement of a cooled electromagnet with a figure-eight coil on the patients scalp and turning on the magnetic flux This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex When an area of the brain is stimulated a period follows when that area cannot be stimulated again In this case researchers plan to use TMS to stimulate the PPC in order to decrease the level of excitability there
Researchers believe that if they can decrease activity in the posterior parietal cortex they may be able to reduce phantom pain
Researchers plan to use low frequency 1 Hz transcranial magnetic stimulation TMS to decrease the excitability of the PPC opposite the side of the amputated limb TMS involves the placement of a cooled electromagnet with a figure-eight coil on the patients scalp and turning on the magnetic flux This permits non-invasive relatively localized stimulation of the surface of the brain cerebral cortex When an area of the brain is stimulated a period follows when that area cannot be stimulated again In this case researchers plan to use TMS to stimulate the PPC in order to decrease the level of excitability there
Detailed Description:
Phantom pain is a chronic painful condition that affects patients with amputations Treatment for phantom pain is often disappointing In amputees hyperexcitability of the posterior parietal cortex area PPC contralateral to the side of the amputation has been linked with the presence of phantom sensations PPC is an area overactive in different forms of chronic pain too It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain a condition poorly responsive to available treatments We have previously demonstrated that low frequency TMS 1 Hz results in decreased excitability of the stimulated cortical regions We plan to apply low-frequency TMS to PPC cortical areas contralateral to the side of the amputated limb We expect that this intervention will result in amelioration of the phantom pain Stimulation of the PPC area target intervention will be compared with a control intervention in which TMS is directed slightly away from the head
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-N-0022 | None | None | None |