Ignite Creation Date:
2024-07-17 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06470516
Status:
RECRUITING
Last Update Posted:
2024-06-24
First Post:
2024-06-17
Brief Title:
The Hi-tACS on Cognitive Function in Patients With Schizophrenia
Sponsor:
Sir Run Run Shaw Hospital
Organization:
Sir Run Run Shaw Hospital
Study Overview
Official Title:
The Impact of High-frequency Transcranial Alternating Current Stimulation Hi-tACS on Cognitive Function in Patients With Schizophrenia
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a double-blind randomized controlled intervention study aimed at exploring whether high-frequency transcranial alternating current stimulation Hi-tACS can improve cognitive impairment in patients with schizophrenia
Detailed Description:
Schizophrenia is a chronic severe mental disorder characterized by a high suicide rate and significant disability Cognitive impairment is one of the core symptoms of schizophrenia with approximately 98 of patients experiencing a decline in cognitive function compared to pre-illness levels Research has found that individuals with schizophrenia show significant impairments in seven domains including reaction time attention working memory verbal learning and memory visual learning and memory logical reasoning and social cognition
Pharmacological treatment remains the primary approach for managing schizophrenia However cognitive impairment in individuals with schizophrenia often does not respond well to medication Additionally electroconvulsive therapy ECT may have potential cognitive side effects Transcranial alternating current stimulation tACS a form of noninvasive brain stimulation has been found in several studies to improve cognition However its effectiveness is not yet clear
Conventional tACS utilizes weak currents below 4mA which can only directly stimulate certain cortical areas and indirectly stimulate deep brain structures Moreover the targeting of specific brain regions can be complex and users may experience a sensation of heat on the skin where the electrodes come into contactHigh-frequency transcranial alternating current stimulation Hi-tACS employs electrical currents greater than 10mA typically ranging from 10-15mA Unlike conventional tACS Hi-tACS can apply stimulation to the entire brain potentially enhancing its therapeutic effects Moreover Hi-tACS does not require precise targeting and is generally well-tolerated without any discomfort during the stimulation It is considered a promising and potentially safe treatment modality for cognitive impairment in schizophrenia
Pharmacological treatment remains the primary approach for managing schizophrenia However cognitive impairment in individuals with schizophrenia often does not respond well to medication Additionally electroconvulsive therapy ECT may have potential cognitive side effects Transcranial alternating current stimulation tACS a form of noninvasive brain stimulation has been found in several studies to improve cognition However its effectiveness is not yet clear
Conventional tACS utilizes weak currents below 4mA which can only directly stimulate certain cortical areas and indirectly stimulate deep brain structures Moreover the targeting of specific brain regions can be complex and users may experience a sensation of heat on the skin where the electrodes come into contactHigh-frequency transcranial alternating current stimulation Hi-tACS employs electrical currents greater than 10mA typically ranging from 10-15mA Unlike conventional tACS Hi-tACS can apply stimulation to the entire brain potentially enhancing its therapeutic effects Moreover Hi-tACS does not require precise targeting and is generally well-tolerated without any discomfort during the stimulation It is considered a promising and potentially safe treatment modality for cognitive impairment in schizophrenia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None