Ignite Creation Date:
2024-07-17 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06467318
Status:
RECRUITING
Last Update Posted:
2024-06-21
First Post:
2024-06-09
Brief Title:
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural AbrasionPleurectomy for Treatment of Pneumothorax
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
Does Non-Steroidal Anti-inflammatory Drugs Decrease the Quality of Pleurodesis After Mechanical Pleural AbrasionPleurectomy for Treatment of Pneumothorax
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Investigators aim to assess if NSAIDs affect the quality of pleurodesis resulting from mechanical pleurodesis open surgery or VATS regarding Primary outcome Recurrence of pneumothorax in 6 monthes assessed by X ray after 2 weeks and 6 months or symptoms requiring X ray at any timing Secondary outcome Adjusted Length of stay from day zero surgery day to discharge Time of removal of the chest Tube relatively longer with air leak presence Need of opioids N-SAID may decrease the need of opioids
Detailed Description:
Pneumothorax is a relatively common clinical problem which can occur in individuals of any age Irrespective of aetiology primary or secondary to lung disorders or injury immediate management depends on the extent of cardiorespiratory impairment degree of symptoms and size of pneumothoraxNon-steroidal anti-inflammatory drugs NSAIDs are being used with increasing frequency due to their potent analgesic effects without having side-effects on the central neural system and additionally due to the large number and varieties of these agents The analgesic antiinflammatory properties and efficacy of NSAIDs in a wide variety of diseases have been already established Wound healing and formation of adhesions involve inflammation cell proliferation matrix deposition and neovascularization The exact mechanism by which NSAIDs affect collagen deposition and the time course of the events leading to the formation of fibrin and of adhesions after pleurodesis have not been completely elucidated until now NSAIDs can inhibit the inflammatory process and the formation of fibrosis due to their ability to suppress prostaglandin synthesis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None