Ignite Creation Date:
2024-07-17 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06482749
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-01
First Post:
2024-06-23
Brief Title:
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Sponsor:
Peking University First Hospital
Organization:
Peking University First Hospital
Study Overview
Official Title:
Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment A Randomized Double-blinded Sham-controlled Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery DNR and postoperative neurocognitive disorder POCD Repetitive transcranial magnetic stimulation rTMS has been used to improve cognitive function in patients with cognitive impairement This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment
Detailed Description:
Mild cognitive impairment MCI affects 10-15 of the population over 65 years old In patients for elective non-cardiac and emergency surgeries the pooled prevalences of unrecognized cognitive impairment were 370 and 500 respectively Patients with preoperative cognitive impairment are at increased risk of delayed neurocognitive recovery DNR and postoperative neurocognitive disorder POCD Therefore perioperative neurocognitive protection is particularly important for patients with preoperative cognitive impairment
Repetitive transcranial magnetic stimulation rTMS is a neural modulation technique By acting on the brain and altering the membrane potential of cortical neurons the generated pulsed magnetic fields affect neural metabolism and electrical activity and trigger a series of physiological and biochemical reactions It was found that high frequency 5 Hz rTMS increases cortical excitability whereas low frequency 1Hz rTMS reduces corticol excitability The mechanism by which rTMS regulates brain function is generally believed to be related to the long-term enhancement and long-term inhibition of synaptic transmission function
The left dorsolateral prefrontal cortex DLPFC is an important target of rTMS intervention for improving cognitive function A meta-analysis showed that high-frequency rTMS on the DLPFC and low-frequency rTMS on the right medial prefrontal cortex improved memory function high frequency rTMS on the right inferior frontal gyrus enhanced executive ability in non-surgical patients with mild cognitive impairment or Alzheimers disease Another meta-analysis showed that high-frequency rTMS on DLPFC is an effective therapeutic option for improving cognitive function in Alzheimer patients
This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment
Repetitive transcranial magnetic stimulation rTMS is a neural modulation technique By acting on the brain and altering the membrane potential of cortical neurons the generated pulsed magnetic fields affect neural metabolism and electrical activity and trigger a series of physiological and biochemical reactions It was found that high frequency 5 Hz rTMS increases cortical excitability whereas low frequency 1Hz rTMS reduces corticol excitability The mechanism by which rTMS regulates brain function is generally believed to be related to the long-term enhancement and long-term inhibition of synaptic transmission function
The left dorsolateral prefrontal cortex DLPFC is an important target of rTMS intervention for improving cognitive function A meta-analysis showed that high-frequency rTMS on the DLPFC and low-frequency rTMS on the right medial prefrontal cortex improved memory function high frequency rTMS on the right inferior frontal gyrus enhanced executive ability in non-surgical patients with mild cognitive impairment or Alzheimers disease Another meta-analysis showed that high-frequency rTMS on DLPFC is an effective therapeutic option for improving cognitive function in Alzheimer patients
This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None