Ignite Creation Date:
2024-07-17 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06491667
Status:
RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-07-01
Brief Title:
NLR AND CRP Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Neutrophil-to-Lymphocyte Ratio AND C-REATIVE PROTEIN Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute myocardial infarction AMI is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide
Atherosclerosis of coronary arteries which takes decades to manifest clinically is the primary predisposing pathologic factor responsible for the development of coronary heart disease It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques
Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis Destabilization of chronic artery plaques and development of thrombosis which are the main mechanisms in the pathophysiology of ST-segment elevation myocardial infarction STEMI
and the interest to the evaluation of inflammatory biomarkers in coronary artery disease CAD has been increasing over the last decade
Although numerous inflammatory markers including troponin TI lactate dehydrogenase LDH and creatine kinase CK-MB are linked to worsened clinical outcomes in both ST elevation and non-ST elevation myocardial infarction NSTEMI there is an unmet need for a cost-effective biomarker for impoverished countries of the world
The neutrophil-to-lymphocyte ratio NLR and C-reactive protein CRP has emerged as an important inflammatory markers for cardiovascular risk stratification
And are relatively cheap inflammatory markers can act as a bridge to mitigate the gap in assessing the cardiovascular risk and outcomes
Atherosclerosis of coronary arteries which takes decades to manifest clinically is the primary predisposing pathologic factor responsible for the development of coronary heart disease It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques
Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis Destabilization of chronic artery plaques and development of thrombosis which are the main mechanisms in the pathophysiology of ST-segment elevation myocardial infarction STEMI
and the interest to the evaluation of inflammatory biomarkers in coronary artery disease CAD has been increasing over the last decade
Although numerous inflammatory markers including troponin TI lactate dehydrogenase LDH and creatine kinase CK-MB are linked to worsened clinical outcomes in both ST elevation and non-ST elevation myocardial infarction NSTEMI there is an unmet need for a cost-effective biomarker for impoverished countries of the world
The neutrophil-to-lymphocyte ratio NLR and C-reactive protein CRP has emerged as an important inflammatory markers for cardiovascular risk stratification
And are relatively cheap inflammatory markers can act as a bridge to mitigate the gap in assessing the cardiovascular risk and outcomes
Detailed Description:
Acute myocardial infarction AMI is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide
Atherosclerosis of coronary arteries which takes decades to manifest clinically is the primary predisposing pathologic factor responsible for the development of coronary heart disease
It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques
Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis Destabilization of chronic artery plaques and development of thrombosis which are the main mechanisms in the pathophysiology of ST-segment elevation myocardial infarction STEMI
and the interest to the evaluation of inflammatory biomarkers in coronary artery disease CAD has been increasing over the last decade
Although numerous inflammatory markers including troponin TI lactate dehydrogenase LDH and creatine kinase CK-MB are linked to worsened clinical outcomes in both ST elevation and non-ST elevation myocardial infarction NSTEMI there is an unmet need for a cost-effective biomarker for impoverished countries of the world
The neutrophil-to-lymphocyte ratio NLR and C-reactive protein CRP
has emerged as an important inflammatory markers for cardiovascular risk stratification
And are relatively cheap inflammatory markers can act as a bridge to mitigate the gap in assessing the cardiovascular risk and outcomes In patients with acute myocardial infarction
Recent data indicates a strong independent relationship between increased complications after acute myocardial infarction in patients with a high NLR and high CRP level at admission and the initial post-hospitalization period
Accordingly we designed this study to assess the predictive value and prognosis of NLR and CRP in ST-elevation myocardial infarction STEMI
Atherosclerosis of coronary arteries which takes decades to manifest clinically is the primary predisposing pathologic factor responsible for the development of coronary heart disease
It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques
Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis Destabilization of chronic artery plaques and development of thrombosis which are the main mechanisms in the pathophysiology of ST-segment elevation myocardial infarction STEMI
and the interest to the evaluation of inflammatory biomarkers in coronary artery disease CAD has been increasing over the last decade
Although numerous inflammatory markers including troponin TI lactate dehydrogenase LDH and creatine kinase CK-MB are linked to worsened clinical outcomes in both ST elevation and non-ST elevation myocardial infarction NSTEMI there is an unmet need for a cost-effective biomarker for impoverished countries of the world
The neutrophil-to-lymphocyte ratio NLR and C-reactive protein CRP
has emerged as an important inflammatory markers for cardiovascular risk stratification
And are relatively cheap inflammatory markers can act as a bridge to mitigate the gap in assessing the cardiovascular risk and outcomes In patients with acute myocardial infarction
Recent data indicates a strong independent relationship between increased complications after acute myocardial infarction in patients with a high NLR and high CRP level at admission and the initial post-hospitalization period
Accordingly we designed this study to assess the predictive value and prognosis of NLR and CRP in ST-elevation myocardial infarction STEMI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None