Ignite Creation Date:
2024-07-17 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06476067
Status:
RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-06-21
Brief Title:
Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
Sponsor:
City of Hope Medical Center
Organization:
City of Hope Medical Center
Study Overview
Official Title:
Predicting Postoperative Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prognosis of patients with esophageal squamous cell carcinoma ESCC who develop post-operative early tumor recurrence is often relatively poor Therefore biomarker that can detect micro metastases before the start of treatment is required Epigenomic alterations such as DNA methylation have attracted attention as promising biomarkers The investigators aim to predict early recurrence based on whole genome DNA methylation analysis of esophageal cancer
Detailed Description:
Prognosis for patients with esophageal squamous cell carcinoma ESCC remains poor Surgery is one of the standard treatments for patients with ESCC who are considered to have a curative resection however approximately 40 of patients develop tumor recurrence within two years after surgery The main cause of poor prognosis in ESCC patients undergoing surgery is postoperative tumor recurrence due to the presence of latent micro-metastases at the time of surgery Even with todays advances in preoperative diagnostic techniques predicting early tumor recurrence remains difficult due to the lack of established methods Epigenetic markers especially DNA methylation are considered ideal markers for predicting cancer metastasis due to their cancer-specific methylation patterns biological stability and technical reproducibility Our study aims to evaluate methylation of surgical specimens to assess residual disease and predict early recurrence
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None